Comparative Study
doi: 10.1007/BF01659767.
Efficacy of bacampicillin and ampicillin in experimental pyelonephritis in the rat
- PMID: 389822
- DOI: 10.1007/BF01659767
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Comparative Study
Efficacy of bacampicillin and ampicillin in experimental pyelonephritis in the rat
Infection.
1979.
Abstract
Bacampicillin and ampicillin were tested and compared with each other in a model of acute, obstructive pyelonephritis in the rat. The compounds were administered orally at five dose levels ranging from 50 mg/kg to 150 mg/kg. Bacampicillin was found to have a greater therapeutic activity than ampicillin, particulary at the higher doses, indicating that its improved absorption properties make it a therapeutically more effective compound than ampicillin.
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