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. 2024 Nov-Dec;41(6):1127-1130.
doi: 10.1111/pde.15693. Epub 2024 Jul 9.

Characterizing drug-induced epidermal necrolysis in a pediatric cohort

Ariel B Brown  1 , Andrew J Park  2 , Nnenna G Agim  3   4 , Katherine A Gordon  1
Affiliations

Characterizing drug-induced epidermal necrolysis in a pediatric cohort

Ariel B Brown et al. Pediatr Dermatol. 2024 Nov-Dec.

Abstract

This study aims to characterize the timeline and clinical features of onset, progression, and management of drug-induced epidermal necrolysis in pediatric patients. Sixteen pediatric patients were retrospectively identified and selected if under age 18 years at admission with one identified culprit drug exposure. Culprit drugs were antiepileptics (12/16, 75%) and antibiotics (4/16, 25%). Notably, anti-epileptic drugs (AED) had delayed onset and reported dose escalations that precipitated symptom onset; thus, patients prescribed AED with or without planned dose escalations should be monitored for prodromal symptoms longer than the typical onset window.

Keywords: Stevens–Johnson syndrome; anti‐epileptic drugs; drug reaction; drug‐induced epidermal necrolysis; toxic epidermal necrolysis.

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References

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