Ablation of oligodendrogenesis in adult mice alters brain microstructure and activity independently of behavioral deficits

doi:10.1002/glia.24576

. 2024 Oct;72(10):1728-1745.

doi: 10.1002/glia.24576. Epub 2024 Jul 9.

Ablation of oligodendrogenesis in adult mice alters brain microstructure and activity independently of behavioral deficits

Affiliations

¹ Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
² Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht & Utrecht University, Utrecht, The Netherlands.
³ Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
⁴ Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
⁵ The Wolfson Institute for Biomedical Research, University College London, London, UK.
⁶ Department of Experimental Psychology, University of Oxford, Oxford, UK.
⁷ Sir Jules Thorn Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.
⁸ The Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.
⁹ School of Psychology and Neuroscience, University of Glasgow, Glasgow, UK.

PMID: 38982743
DOI: 10.1002/glia.24576

Ablation of oligodendrogenesis in adult mice alters brain microstructure and activity independently of behavioral deficits

Malte S Kaller et al. Glia. 2024 Oct.

. 2024 Oct;72(10):1728-1745.

doi: 10.1002/glia.24576. Epub 2024 Jul 9.

Authors

Affiliations

¹ Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
² Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht & Utrecht University, Utrecht, The Netherlands.
³ Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
⁴ Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
⁵ The Wolfson Institute for Biomedical Research, University College London, London, UK.
⁶ Department of Experimental Psychology, University of Oxford, Oxford, UK.
⁷ Sir Jules Thorn Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.
⁸ The Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.
⁹ School of Psychology and Neuroscience, University of Glasgow, Glasgow, UK.

PMID: 38982743
DOI: 10.1002/glia.24576

Abstract

Oligodendrocytes continue to differentiate from their precursor cells even in adulthood, a process that can be modulated by neuronal activity and experience. Previous work has indicated that conditional ablation of oligodendrogenesis in adult mice leads to learning and memory deficits in a range of behavioral tasks. The current study replicated and re-evaluated evidence for a role of oligodendrogenesis in motor learning, using a complex running wheel task. Further, we found that ablating oligodendrogenesis alters brain microstructure (ex vivo MRI) and brain activity (in vivo EEG) independent of experience with the task. This suggests a role for adult oligodendrocyte formation in the maintenance of brain function and indicates that task-independent changes due to oligodendrogenesis ablation need to be considered when interpreting learning and memory deficits in this model.

Keywords: EEG; Myrf; motor learning; myelin; oligodendrocytes; plasticity; preclinical MRI.

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References

REFERENCES

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1. Bergles, D. E., & Richardson, W. D. (2016). Oligodendrocyte development and plasticity. Cold Spring Harbor Perspectives in Biology, 8, a020453. https://doi.org/10.1101/cshperspect.a020453
1. Bonetto, G., Belin, D., & Káradóttir, R. T. (2021). Myelin: A gatekeeper of activity‐dependent circuit plasticity? Science, 374, eaba6905. https://doi.org/10.1126/science.aba6905
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[1] Avants, B. B., Epstein, C. L., Grossman, M., & Gee, J. C. (2008). Symmetric diffeomorphic image registration with cross‐correlation: Evaluating automated labeling of elderly and neurodegenerative brain. Medical Image Analysis, 12, 26–41. https://doi.org/10.1016/j.media.2007.06.004

[2] Avants, B. B., Epstein, C. L., Grossman, M., & Gee, J. C. (2008). Symmetric diffeomorphic image registration with cross‐correlation: Evaluating automated labeling of elderly and neurodegenerative brain. Medical Image Analysis, 12, 26–41. https://doi.org/10.1016/j.media.2007.06.004

[3] Bacmeister, C. M., Huang, R., Osso, L. A., Thornton, M. A., Conant, L., Chavez, A., Poleg‐Polsky, A., & Hughes, E. G. (2022). Motor learning drives dynamic patterns of intermittent myelination on learning‐activated axons. Nature Neuroscience, 25, 1300–1313. https://doi.org/10.1101/2021.10.13.464319

[4] Bacmeister, C. M., Huang, R., Osso, L. A., Thornton, M. A., Conant, L., Chavez, A., Poleg‐Polsky, A., & Hughes, E. G. (2022). Motor learning drives dynamic patterns of intermittent myelination on learning‐activated axons. Nature Neuroscience, 25, 1300–1313. https://doi.org/10.1101/2021.10.13.464319

[5] Bergles, D. E., & Richardson, W. D. (2016). Oligodendrocyte development and plasticity. Cold Spring Harbor Perspectives in Biology, 8, a020453. https://doi.org/10.1101/cshperspect.a020453

[6] Bergles, D. E., & Richardson, W. D. (2016). Oligodendrocyte development and plasticity. Cold Spring Harbor Perspectives in Biology, 8, a020453. https://doi.org/10.1101/cshperspect.a020453

[7] Bonetto, G., Belin, D., & Káradóttir, R. T. (2021). Myelin: A gatekeeper of activity‐dependent circuit plasticity? Science, 374, eaba6905. https://doi.org/10.1126/science.aba6905

[8] Bonetto, G., Belin, D., & Káradóttir, R. T. (2021). Myelin: A gatekeeper of activity‐dependent circuit plasticity? Science, 374, eaba6905. https://doi.org/10.1126/science.aba6905

[9] Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994). Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. Journal of Computer Assisted Tomography, 18, 192–205.

[10] Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994). Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. Journal of Computer Assisted Tomography, 18, 192–205.

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Ablation of oligodendrogenesis in adult mice alters brain microstructure and activity independently of behavioral deficits

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Ablation of oligodendrogenesis in adult mice alters brain microstructure and activity independently of behavioral deficits

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