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. 2024 Oct;72(10):1728-1745.
doi: 10.1002/glia.24576. Epub 2024 Jul 9.

Ablation of oligodendrogenesis in adult mice alters brain microstructure and activity independently of behavioral deficits

Malte S Kaller  1 , Alberto Lazari  1 , Yingshi Feng  1 , Annette van der Toorn  2 , Sebastian Rühling  1   3 , Christopher W Thomas  4 , Takahiro Shimizu  5 , David Bannerman  6 , Vladyslav Vyazovskiy  4   7   8 , William D Richardson  5 , Cassandra Sampaio-Baptista  1   9 , Heidi Johansen-Berg  1
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Ablation of oligodendrogenesis in adult mice alters brain microstructure and activity independently of behavioral deficits

Malte S Kaller et al. Glia. 2024 Oct.

Abstract

Oligodendrocytes continue to differentiate from their precursor cells even in adulthood, a process that can be modulated by neuronal activity and experience. Previous work has indicated that conditional ablation of oligodendrogenesis in adult mice leads to learning and memory deficits in a range of behavioral tasks. The current study replicated and re-evaluated evidence for a role of oligodendrogenesis in motor learning, using a complex running wheel task. Further, we found that ablating oligodendrogenesis alters brain microstructure (ex vivo MRI) and brain activity (in vivo EEG) independent of experience with the task. This suggests a role for adult oligodendrocyte formation in the maintenance of brain function and indicates that task-independent changes due to oligodendrogenesis ablation need to be considered when interpreting learning and memory deficits in this model.

Keywords: EEG; Myrf; motor learning; myelin; oligodendrocytes; plasticity; preclinical MRI.

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