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Case Reports
. 2024 Jun 26;12(18):3609-3614.
doi: 10.12998/wjcc.v12.i18.3609.

Parathyroid carcinoma located in the thyroid gland: A case report

Shu-Yan Gui  1 , Chang-Ning Zhang  1 , Li Ling  1 , Ruo-Xi Tang  1 , Jing Yang  2
Affiliations
Case Reports

Parathyroid carcinoma located in the thyroid gland: A case report

Shu-Yan Gui et al. World J Clin Cases. .

Abstract

Background: Parathyroid carcinoma (PC) is a difficult-to-diagnose rare disease with low incidence. Relatively accurate preoperative diagnosis is very important in choosing surgical methods and patient prognosis.

Case summary: This study reported the clinical diagnosis and treatment of a rare patient with PC located in the thyroid gland and provided a case reference for the diagnosis and treatment of PC. A case of a 64-year-old male patient who presented to our hospital with systemic muscle and joint pain and palpitations is outlined. Subsequently, the patient was admitted to the Department of Nephrology for the treatment of "multiple myeloma nephropathy pending investigation". The patient was diagnosed with "primary hyperparathyroidism and hypercalcemic crisis" using thyroid color ultrasound.

Conclusion: The intraoperative frozen section report considered the parathyroid tumor. Surgical tumor resection was promptly performed, and the diagnosis of PC was confirmed.

Keywords: Case report; Fine needle aspiration; Intraoperative frozen section; Parathyroid carcinoma; Surgical resection.

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Conflict of interest statement

Conflict-of-interest statement: All the authors declare that they have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Colored ultrasound of the thyroid gland and cervical lymph nodes. A-C: The left lobe of the thyroid gland is enlarged, the right lobe is not large, and the echogenicity of glandular tissue is uneven. A mixed echogenic mass of about 38 mm × 30 mm was found in the left lobe of the thyroid, with a clear boundary and regular shape. Several strong echogenic spots of different sizes were observed inside, accompanied by acoustic shadow behind.
Figure 2
Figure 2
Parathyroid imaging (MIBI). A-C: A concentrated shadow of radioactivity in the left lobe of the thyroid.
Figure 3
Figure 3
Fine needle aspiration cytological smear of thyroid nodules. A-C: Patches of thyroid follicular epithelium with crowded cells were detected. Some cells showed intranuclear pseudoinclusions, and nuclear furrows were rare. The pathological case was considered papillary thyroid carcinoma.
Figure 4
Figure 4
Pathological findings. A: Fiber separation (10×); B: Capsular invasion (10×); C: Endovascular invasion (10×); D: Fatty infiltration (10×). E: Heterocyst (40×); F: Parathyroid hormone staining (40×); G: Ki67 staining (40×); H: Calcitonin staining (40×).
See this image and copyright information in PMC

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