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Review
. 2024 Jun 19:19:e08.
doi: 10.15420/ecr.2023.28. eCollection 2024.

Maternal Cardiac Function in Pregnancies with Metabolic Disorders

Deesha Patel  1 , Makrina D Savvidou  1   2
Affiliations
Review

Maternal Cardiac Function in Pregnancies with Metabolic Disorders

Deesha Patel et al. Eur Cardiol. .

Abstract

The obesity epidemic is growing and poses significant risks to pregnancy. Metabolic impairment can be associated with short- and long-term maternal and perinatal morbidity and mortality. The cardiovascular implications are known in those with metabolic disorder outside of pregnancy; however, little is known of the cardiac function in pregnancies complicated by obesity. Maternal cardiac adaptation plays a vital role in normal pregnancy and is known to be involved in the pathophysiology of adverse pregnancy outcomes. Bariatric surgery is the most successful treatment for sustainable weight loss and pre-pregnancy bariatric surgery can drastically change the maternal metabolic profile and pregnancy outcomes. In this review, we discuss the available evidence on maternal cardiac function in pregnancies affected by obesity and its associated consequences of gestational diabetes and hypertension (chronic and hypertensive disorders in pregnancy), as well as pregnancies following bariatric surgery.

Keywords: Pregnancy; diabetes; hypertension in pregnancy; metabolic disorders; obesity.

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Conflict of interest statement

Disclosure: The authors have no conflicts of interest to declare.

Figures

Figure 1:
Figure 1:. Maternal Cardiac Adaptation in Normal Pregnancy and in Women with Obesity[32,40]
Figure 2:
Figure 2:. Left Ventricular Hypertrophy
Figure 3:
Figure 3:. Cardiac Function in Pregnancies with Metabolic Disorders
See this image and copyright information in PMC

References

    1. WHOn. Obesity and overweight. 2022. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (accessed 1 March 2023)
    1. NHS Digital. Statistics on obesity, physical activity and diet (replaced by Statistics on Public Health). 2022. https://digital.nhs.uk/data-and-information/publications/statistical/sta... (accessed 3 May 2023)
    1. Wang YC, McPherson K, Marsh T et al. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet. 2011;378:815–25. doi: 10.1016/S0140-6736(11)60814-3. - DOI - PubMed
    1. Yu CKH, Teoh TG, Robinson S. Obesity in pregnancy. BJOG. 2006;113:1117–25. doi: 10.1111/j.1471-0528.2006.00991.x. - DOI - PubMed
    1. May L. Cardiac physiology of pregnancy. Compr Physiol. 2015;5:1325–44. doi: 10.1002/cphy.c140043. - DOI - PubMed

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