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Review
. 2024 Sep 1;39(5):0.
doi: 10.1152/physiol.00028.2023.

ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis

Lu Zhang  1 , Qianqian Feng  2 , Wei Kong  2
Affiliations
Free article
Review

ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis

Lu Zhang et al. Physiology (Bethesda). .
Free article

Abstract

Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation and stability of atherosclerotic plaques. This review discusses the contribution of the ECM microenvironment in vascular homeostasis and remodeling in atherosclerosis, highlighting Cartilage oligomeric matrix protein (COMP) and its degrading enzyme ADAMTS7 as examples, and proposes potential avenues for future research aimed at identifying novel therapeutic targets for atherosclerosis based on the ECM microenvironment.

Keywords: ECM turnover; atherosclerosis; extracellular matrix; therapeutic target; vascular homeostasis.

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