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Review
. 2024 Jun-Jul;40(6-7):515-524.
doi: 10.1051/medsci/2024080. Epub 2024 Jul 8.

[Formation, organization and function of invadosomes in cell motility and tumor invasion]

[Article in French]
Cécile Gamblin  1 , Philippe Chavrier  2
Affiliations
Free article
Review

[Formation, organization and function of invadosomes in cell motility and tumor invasion]

[Article in French]
Cécile Gamblin et al. Med Sci (Paris). 2024 Jun-Jul.
Free article

Abstract
in English, French

Invadosome is an umbrella term used to describe a family of cellular structures including podosomes and invadopodia. They serve as contact zones between the cell plasma membrane and extracellular matrix, contributing to matrix remodeling by locally enriched proteolytic enzymes. Invadosomes, which are actin-dependent, are implicated in cellular processes promoting adhesion, migration, and invasion. Invadosomes, which exist in various cell types, play crucial roles in physiological phenomena such as vascularization and bone resorption. Invadosomes are also implicated in pathological processes such as matrix tissue remodeling during metastatic tumor cell invasion. This review summarizes basic information and recent advances about mechanisms underlying podosome and invadopodia formation, their organization and function.

Title: Invadosomes - Entre mobilité et invasion, naviguer dans la dualité des fonctions cellulaires.

Abstract: Le terme « invadosome » désigne une famille de structures cellulaires, comprenant les podosomes et les invadopodes, qui constituent des zones de contact entre la membrane plasmique des cellules et la matrice extracellulaire. Ces structures contribuent au remodelage de la matrice grâce à un enrichissement local en enzymes protéolytiques qui dégradent ses constituants fibrillaires. Les invadosomes, présents dans des types cellulaires variés, contribuent à des processus physiologiques, tels que la vascularisation, ou pathologiques, comme l’invasion des tissus par les cellules métastatiques.

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References

    1. Cambi A, Chavrier P. Tissue remodeling by invadosomes. Fac Rev 2021; 10 : 39.
    1. Linder S, Cervero P, Eddy R, Condeelis J. Mechanisms and roles of podosomes and invadopodia. Nat Rev Mol Cell Biol 2023; 24 : 86–106.
    1. PatersonEK, CourtneidgeSA. Invadosomes are coming : new insights into function and disease relevance. FEBS J 2017 ; 285 : 8–27.
    1. Lin SS, Su YA, Chuang MC, Liu YW. Probing invadosomes : technologies for the analysis of invadosomes. FEBS J 2022; 289 : 5 850–63.
    1. Jasnin M, Hervy J, Balor S, et al. Elasticity of podosome actin networks produces nanonewton protrusive forces. Nat Commun 2022; 13 : 3 842.

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