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Review
. 2024 Jul-Aug;15(4):100950.
doi: 10.1016/j.jaim.2024.100950. Epub 2024 Jul 9.

Comparing efficacy of curcumin with other treatment modalities in oral submucous fibrosis management - A systematic review and meta-analysis

Mandavi Waghmare  1 , Sandeep Pagare  2 , Ketaki Bhor  3 , Richa Srivastava  2 , Reema Manoj  2 , Kapil Gavand  2
Affiliations
Review

Comparing efficacy of curcumin with other treatment modalities in oral submucous fibrosis management - A systematic review and meta-analysis

Mandavi Waghmare et al. J Ayurveda Integr Med. 2024 Jul-Aug.

Abstract

Background: Oral Submucous Fibrosis, OSF is an inflammatory mucosal disorder prevalent in areca nut chewing belts of the world. Although various treatments are available for its management, none provide complete resolution.Curcumin, an indigenous product, improves burning sensation, mouth opening along with other clinical signs of OSF and is potentially viable therapeutic option for its management.

Objectives: To assess the available evidence for employing curcumin in improving symptoms in patients with OSF.

Methods: Systematic search was carried out in e-databases from January 2010 until July 2023 to identify relevant clinical trials comparing curcumin to active and/or nonactive controls (placebo) for the management of OSF.

Results: A total of 20 studies were used for qualitative analysis out of which 11 studies were considered for quantitative synthesis.Curcumin was found to be highly effective in alleviating pain/burning sensation, improving mouth opening (MO), cheek flexibility, tongue protrusion and induces positive histological changes in patients with OSF.The standardized mean difference in mouth opening between both the Curcumin and Multivitamin group showed a statistically significant difference favouring the Curcumin group (SMD, 0.37, 95% CI = 0.18-0.56, p - 0.0001, I2- 0%).

Conclusion: Statistically curcumin was noted to be as effective as Aloe vera, lycopene and steroids in relieving symptoms of OSF in stages 1 and 2 and improving MO. It is seen to improve histopathological picture of lesions thereby suggesting its active role in preventing malignant transformation. Its found to be more effective than multivitamins in improving mouth opening of patients in OSF.

Keywords: Curcumin; Fibroses; Oral submucous; Trismus.

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Conflict of interest statement

Conflict of Interest None.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram.
Fig. 2a
Fig. 2a
Risk of Bias graph.
Fig. 2b
Fig. 2b
Risk of bias of individual studies.
Fig. 3a
Fig. 3a
Forest plot comparing Curcumin with Multivitamin for mouth opening.
Fig. 3b
Fig. 3b
Forest plot comparing Curcumin with Multivitamin for Tongue protrusion.
See this image and copyright information in PMC

References

    1. Rai A., Siddiqui M., Parveen S., Parveen S., Rasheed A., Ali S. Molecular Pathogenesis of oral submucous fibrosis: a Critical Appraisal. Biomed Pharmacol J. 2019;12:2027–2036.
    1. Rao N.R., Villa A., More C.B., et al. Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management. J of Otolaryngol - Head & Neck Surg. 2020;49:1–11. - PMC - PubMed
    1. Murti P.R., Bhonsle R.B., Pindborg J.J., Daftary D.K., Gupta P.C., Mehta F.S. Malignant transformation rate in oral submucous fibrosis over a 17-year period. Community Dent Oral Epidemiol. 1985;13:340–341. - PubMed
    1. Yang S., Wang Y., Su N. Changes in prevalence of precancerous oral submucous fibrosis from 1996 to 2013 in Taiwan: a nationwide population-based retrospective study. J Formos Med Assoc. 2018;117:147–152. - PubMed
    1. Moher D., Liberati A., Tetzlaff J., et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8:336–341. - PubMed

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