RIPK1: Inflamed if you do, inflamed if you don't
- PMID: 38986436
- DOI: 10.1016/j.immuni.2024.06.002
RIPK1: Inflamed if you do, inflamed if you don't
Abstract
RIPK1 is known as a driver of cell death and inflammation. In this issue of Immunity, Imai et al. and Mannion et al. find that these same processes are also induced by RIPK1 inactivation and highlight the therapeutic potential of RIPK1 elimination.
Copyright © 2024 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation.Immunity. 2024 Jul 9;57(7):1497-1513.e6. doi: 10.1016/j.immuni.2024.04.016. Epub 2024 May 13. Immunity. 2024. PMID: 38744293
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