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Comment
. 2024 Jul 9;57(7):1445-1448.
doi: 10.1016/j.immuni.2024.06.006.

The pros and confs of IL-18 activation

Danielle M Clancy  1 , Julie Andries  1 , Savvas N Savvides  2
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Comment

The pros and confs of IL-18 activation

Danielle M Clancy et al. Immunity. .
Free article

Abstract

Interleukin-1 (IL-1) family cytokines are key immunological regulators that achieve their signaling prowess after post-translational proteolytic processing. In this issue of Immunity, Dong et al. reveal the structural consequences of this process on proinflammatory IL-18, demonstrating that pro-IL-18 and mature IL-18 are structurally distinct.

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Declaration of interests The authors declare no competing interests.

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