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Comment
. 2024 Jul 9;57(7):1451-1453.
doi: 10.1016/j.immuni.2024.06.004.

Skin deep: Epithelial cell metabolism and chronic skin inflammation

Eliana R Solis  1 , Julie M Jameson  2
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Comment

Skin deep: Epithelial cell metabolism and chronic skin inflammation

Eliana R Solis et al. Immunity. .

Abstract

Skin inflammation is potentiated by coordinated epithelial and immune cell metabolism. In this issue of Immunity, Subudhi and Konieczny et al. delineate how HIF1α regulates epithelial cell glycolysis during psoriasis. In turn, lactate is a byproduct that augments type 17 γδ T cell responses to sustain inflammatory skin disease.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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