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Comment
. 2024 Jul 9;57(7):1454-1456.
doi: 10.1016/j.immuni.2024.06.007.

B cells! Don't go the wrong way in this tumor

Guilhem Pupier  1 , Catherine Sautès-Fridman  2
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B cells! Don't go the wrong way in this tumor

Guilhem Pupier et al. Immunity. .
Free article

Abstract

The association of tertiary lymphoid structures (TLSs) with survival and immunotherapy response brought B cells to center stage. In a pan-cancer B cells atlas in Science, Ma et al. show that germinal center reaction generating anti-tumor antibody-secreting cells (ASCs) from B memory cells in mature TLSs co-exist in tumors with extra-follicular reaction generating auto-reactive ASCs from memory B cells in immature TLSs.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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  • A blueprint for tumor-infiltrating B cells across human cancers.
    Ma J, Wu Y, Ma L, Yang X, Zhang T, Song G, Li T, Gao K, Shen X, Lin J, Chen Y, Liu X, Fu Y, Gu X, Chen Z, Jiang S, Rao D, Pan J, Zhang S, Zhou J, Huang C, Shi S, Fan J, Guo G, Zhang X, Gao Q. Ma J, et al. Science. 2024 May 3;384(6695):eadj4857. doi: 10.1126/science.adj4857. Epub 2024 May 3. Science. 2024. PMID: 38696569