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. 2024 Oct;39(10):1732-1739.
doi: 10.1002/mds.29922. Epub 2024 Jul 11.

Parkinson's Disease Progression and Exposure to Contaminated Water at Camp Lejeune

Samuel M Goldman  1   2 , Frances M Weaver  3   4 , Beverly Gonzalez  5 , Kevin T Stroupe  3   4 , Lishan Cao  3 , Kalea Colletta  6 , Ethan G Brown  2   7 , Caroline M Tanner  2   7
Affiliations

Parkinson's Disease Progression and Exposure to Contaminated Water at Camp Lejeune

Samuel M Goldman et al. Mov Disord. 2024 Oct.

Abstract

Background: We recently reported an increased risk of Parkinson's disease (PD) in service members who resided at Marine Base Camp Lejeune, North Carolina, when water supplies were contaminated with trichloroethylene and other volatile organic compounds (VOCs). Prior studies suggest that environmental exposures may affect PD phenotype or progression, but this has not been reported for VOCs.

Objective: The objective of this study was to test whether PD progression is faster in individuals exposed to VOCs in water at Camp Lejeune.

Methods: A cohort of 172,128 marines residing at Camp Lejeune between 1975 and 1985 was previously assembled. We identified individuals with PD in Veterans Health Administration and Medicare databases between 2000 and 2021. Using estimates derived by the US Agency for Toxic Substances and Disease Registry, we classified individuals as exposed or unexposed to VOCs in residential water. We used Kaplan-Meier and Cox regression models to test differences between exposed and unexposed groups in the time from PD diagnosis until psychosis, fracture, fall, or death.

Results: Among 270 persons with PD, 177 (65.6%) were exposed to VOCs in residential water. Median cumulative exposure was 4970 μg/L-months, >50-fold the permissible level. Time until psychosis, fracture, and fall were all shorter in the exposed group, with adjusted hazard ratios (HRs) exceeding 2: psychosis HR, 2.19 (95% confidence interval [CI]: 0.99-4.83); fracture HR, 2.44 (95% CI: 0.91-6.55); and fall HR, 2.64 (95% CI: 0.97-7.21). A significant dose response was observed for time to fall (P trend, 0.032). No differences were observed for time until death.

Conclusions: PD progression may be faster in persons exposed to trichloroethylene and other VOCs in water decades earlier. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

Keywords: Parkinson's disease; exposure; progression; solvent; trichloroethylene.

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Conflict of interest statement

Financial Disclosure/Conflict of Interest concerning the research related to the manuscript: None

Figures

Figure 1.
Figure 1.. Kaplan-Meier Survival Curves from PD diagnosis until outcome or 15-years follow-up in TVOC Exposed and Unexposed
a. Psychosis b. Fracture c. Fall d. Death
Figure 1.
Figure 1.. Kaplan-Meier Survival Curves from PD diagnosis until outcome or 15-years follow-up in TVOC Exposed and Unexposed
a. Psychosis b. Fracture c. Fall d. Death
Figure 1.
Figure 1.. Kaplan-Meier Survival Curves from PD diagnosis until outcome or 15-years follow-up in TVOC Exposed and Unexposed
a. Psychosis b. Fracture c. Fall d. Death
Figure 1.
Figure 1.. Kaplan-Meier Survival Curves from PD diagnosis until outcome or 15-years follow-up in TVOC Exposed and Unexposed
a. Psychosis b. Fracture c. Fall d. Death
See this image and copyright information in PMC

References

    1. Greenland JC, Williams-Gray CH, Barker RA. The clinical heterogeneity of Parkinson’s disease and its therapeutic implications. Eur J Neurosci 2019;49(3):328–338. - PubMed
    1. Chase BA, Krueger R, Pavelka L, et al. Multifactorial assessment of Parkinson’s disease course and outcomes using trajectory modeling in a multiethnic, multisite cohort - extension of the LONG-PD study. Front Aging Neurosci 2023;15:1240971. - PMC - PubMed
    1. Simon DK, Tanner CM, Brundin P. Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology. Clin Geriatr Med 2020;36(1):1–12. - PMC - PubMed
    1. Paul KC, Chuang YH, Shih IF, et al. The association between lifestyle factors and Parkinson’s disease progression and mortality. Mov Disord 2019;34(1):58–66. - PMC - PubMed
    1. Brown E, Goldman S, Meng C, Tanner C. Head Injury and Parkinson’s Disease (PD) Phenotype (1261). Neurology 2020;94(15 Supplement):1261.

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