Excellent outcome of children/adolescents with primary mediastinal large B-cell lymphoma treated with a FAB/ LMB-based chemotherapy regimen with rituximab

Marie Emilie Dourthe¹, Anne Auperin², Charlotte Rigaud³, Melissa Barbati⁴, Jacinthe Bonneau⁵, Nimrod Buchbinder⁶, Marie-Laure Couec⁷, Peggy Dartigues⁸, Stéphane Ducassou⁹, Nathalie Garnier¹⁰, Stéphanie Haouy¹¹, Bénédicte Jonca¹², Anne Jourdain¹³, Amaury Leruste¹⁴, Thierry Molina¹⁵, Françoise Montravers¹², Marlène Pasquet¹⁶, Aurélie Phulpin¹⁷, Maryline Poirée¹⁸, Mathieu Simonin¹⁹, Alexandra Spiegel²⁰, Arnauld Verschuur²¹, Thierry Leblanc²², Judith Landman-Parker¹⁹, Catherine Patte³, Véronique Minard-Colin²³

Affiliations

¹ Department of Pediatric Hematology and Immunology, Robert Debré University Hospital, AP-HP and University de Paris, Paris, France; Université Paris Cité, Institut Necker-Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (Inserm) U1151, Paris. dourthe@aphp.fr.
² Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif.
³ Departments of Pediatric and Adolescent Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif.
⁴ Department of Pediatric Oncology and Haematology, University Hospital of Lille, Lille.
⁵ Department of Pediatric Oncology and Haematology, University Hospital of Rennes, Rennes.
⁶ Department of Pediatric Oncology and Haematology, University Hospital of Rouen, Rouen.
⁷ Pediatric hematology and oncology department, University Hospital of Nantes, Nantes.
⁸ Department of Biopathology, Morphology Unit, Gustave Roussy, Université Paris Saclay, Villejuif.
⁹ Department of Pediatric Oncology and Haematology, University Hospital of Bordeaux, Bordeaux.
¹⁰ Institut d'Hématologie et d'Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon.
¹¹ Department of Pediatric Oncology and Haematology, University Hospital of Montpellier, Montpellier.
¹² Department of nuclear medicine, University Hospital Tenon, Paris.
¹³ Department of Pediatric Oncology and Haematology, University Hospital of Tours, Tours.
¹⁴ SIREDO Oncology Center, Institut Curie, PSL Research University, Paris.
¹⁵ Department of biopathology, University Hospital Necker Enfants Malades, Université Paris Cité, Paris.
¹⁶ Department of Pediatric Oncology and Haematology, University Hospital of Toulouse, Toulouse.
¹⁷ Pediatric Oncology and Hematology Department, University Hospital of Nancy (CHRU Nancy), Nancy.
¹⁸ Department of Pediatric Oncology and Haematology, University Hospital of Nice, Nice.
¹⁹ Pediatric Hematology Oncology Department, Sorbonne Université/Trousseau Hospital, APHP, Paris.
²⁰ Pediatric Hematology Oncology Department, University Hospital of Strasbourg, Strasbourg.
²¹ Department of Pediatric Hematology Immunology and Oncology, La Timone Hospital, APHM, Marseille.
²² Department of Pediatric Hematology and Immunology, Robert Debré University Hospital, AP-HP and University de Paris, Paris.
²³ Departments of Pediatric and Adolescent Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France; INSERM Unité 1015. veronique.minard@gustaveroussy.fr.

PMID: 38988265
PMCID: PMC11532712
DOI: 10.3324/haematol.2024.285403

Excellent outcome of children/adolescents with primary mediastinal large B-cell lymphoma treated with a FAB/ LMB-based chemotherapy regimen with rituximab

Marie Emilie Dourthe et al. Haematologica. 2024.

. 2024 Nov 1;109(11):3790-3794.

doi: 10.3324/haematol.2024.285403.

Authors

Affiliations

¹ Department of Pediatric Hematology and Immunology, Robert Debré University Hospital, AP-HP and University de Paris, Paris, France; Université Paris Cité, Institut Necker-Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (Inserm) U1151, Paris. dourthe@aphp.fr.
² Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif.
³ Departments of Pediatric and Adolescent Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif.
⁴ Department of Pediatric Oncology and Haematology, University Hospital of Lille, Lille.
⁵ Department of Pediatric Oncology and Haematology, University Hospital of Rennes, Rennes.
⁶ Department of Pediatric Oncology and Haematology, University Hospital of Rouen, Rouen.
⁷ Pediatric hematology and oncology department, University Hospital of Nantes, Nantes.
⁸ Department of Biopathology, Morphology Unit, Gustave Roussy, Université Paris Saclay, Villejuif.
⁹ Department of Pediatric Oncology and Haematology, University Hospital of Bordeaux, Bordeaux.
¹⁰ Institut d'Hématologie et d'Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon.
¹¹ Department of Pediatric Oncology and Haematology, University Hospital of Montpellier, Montpellier.
¹² Department of nuclear medicine, University Hospital Tenon, Paris.
¹³ Department of Pediatric Oncology and Haematology, University Hospital of Tours, Tours.
¹⁴ SIREDO Oncology Center, Institut Curie, PSL Research University, Paris.
¹⁵ Department of biopathology, University Hospital Necker Enfants Malades, Université Paris Cité, Paris.
¹⁶ Department of Pediatric Oncology and Haematology, University Hospital of Toulouse, Toulouse.
¹⁷ Pediatric Oncology and Hematology Department, University Hospital of Nancy (CHRU Nancy), Nancy.
¹⁸ Department of Pediatric Oncology and Haematology, University Hospital of Nice, Nice.
¹⁹ Pediatric Hematology Oncology Department, Sorbonne Université/Trousseau Hospital, APHP, Paris.
²⁰ Pediatric Hematology Oncology Department, University Hospital of Strasbourg, Strasbourg.
²¹ Department of Pediatric Hematology Immunology and Oncology, La Timone Hospital, APHM, Marseille.
²² Department of Pediatric Hematology and Immunology, Robert Debré University Hospital, AP-HP and University de Paris, Paris.
²³ Departments of Pediatric and Adolescent Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France; INSERM Unité 1015. veronique.minard@gustaveroussy.fr.

PMID: 38988265
PMCID: PMC11532712
DOI: 10.3324/haematol.2024.285403

No abstract available

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Figures

**Figure 1.**
**Kaplan-Meier estimates of event-free survival and overall survival in the entire cohort.** EFS: event-free survival; OS: overall survival.

See this image and copyright information in PMC

References

1. Alaggio R, Amador C, Anagnostopoulos I, et al. . The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia. 2022;36(7):1720-1748. - PMC - PubMed
1. Burkhardt B, Zimmermann M, Oschlies I, et al. . The impact of age and gender on biology, clinical features and treatment outcome of non-Hodgkin lymphoma in childhood and adolescence. Br J Haematol. 2005;131(1):39-49. - PubMed
1. Martelli M, Di Rocco A, Russo E, Perrone S, Foà R. Primary mediastinal lymphoma: diagnosis and treatment options. Expert Rev Hematol. 2015;8(2):173-186. - PubMed
1. Patte C, Auperin A, Michon J, et al. . The Société Française d’Oncologie Pédiatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia. Blood. 2001;97(11):3370-3379. - PubMed
1. Patte C, Auperin A, Gerrard M, et al. . Results of the randomized international FAB/LMB96 trial for intermediate risk B-cell non-Hodgkin lymphoma in children and adolescents: it is possible to reduce treatment for the early responding patients. Blood. 2007;109(7):2773-2780. - PMC - PubMed

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Excellent outcome of children/adolescents with primary mediastinal large B-cell lymphoma treated with a FAB/ LMB-based chemotherapy regimen with rituximab

Affiliations

Excellent outcome of children/adolescents with primary mediastinal large B-cell lymphoma treated with a FAB/ LMB-based chemotherapy regimen with rituximab

Authors

Affiliations

Figures

References

LinkOut - more resources

Full Text Sources