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. 2024 Mar 31;39(2):e607.
doi: 10.5001/omj.2024.55. eCollection 2024 Mar.

Immunohistochemical Expression of Ki-67 and p53 and Their Prognostic Role in Ameloblastoma: A Longitudinal Study

James J Yahaya  1 , Phenehas Bwambale  2 , Emmanuel D Morgan  1 , Zephania S Abraham  3 , Gelardine Owor  2 , Henry Wabinga  2
Affiliations

Immunohistochemical Expression of Ki-67 and p53 and Their Prognostic Role in Ameloblastoma: A Longitudinal Study

James J Yahaya et al. Oman Med J. .

Abstract

Objectives: Ameloblastoma, comprising approximately 11% of all odontogenic tumors, is a locally aggressive tumor with a high recurrence rate. This study aimed to assess the immunohistochemical expression of Ki-67 and p53 and their association with clinical and pathological factors among patients with ameloblastoma.

Methods: Retrospective follow-up data of patients histologically confirmed with ameloblastoma at Makerere College of Health Sciences in Kampala, Uganda from January 2012 to December 2018 were retrieved. Factors associated with Ki-67 and p53 immunohistochemical expression were determined using one-way one-way analysis of variance. Chi-square and Fisher's exact statistical tests were used to assess factors associated with recurrence. A two-tailed p < 0.05 was considered statistically significant.

Results: A total of 40 patients confirmed histologically with ameloblastoma were included in the analysis. The majority (62.5%) of cases were of the conventional type of ameloblastoma. The expressions of Ki-67 and p53 were 52.5% and 85.0%, respectively. Recurrence was found in 47.5% of patients and it was associated with conventional histological type (p=0.042), segmental resection (p < 0.001), tumor size (p < 0.001), and high p53 expression (p=0.041).

Conclusions: Almost half the cases in this study had recurrence. The immunohistochemical expression of p53 was significantly higher than that of Ki-67.

Keywords: Ameloblastoma; Ki-67 Antigen; Tumor Suppressor Protein p53.

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Figures

Figure 1
Figure 1
(a) Weak intranuclear staining for anti-Ki-67 for the case of follicular ameloblastoma (magnification = 100 ×), (b) moderate intranuclear staining for anti-Ki-67 for the case of peripheral ameloblastoma (magnification = 100 ×), and (c) strong intranuclear staining for anti-Ki-67 for plexiform ameloblastoma (magnification = 200 ×).
Figure 2
Figure 2
(a) Weak intranuclear staining for p53 protein for the case of peripheral ameloblastoma (magnification = 100 ×), (b) moderate intranuclear staining for p53 protein for the case of basal ameloblastoma (magnification = 100 ×), and (c) strong intranuclear staining for p53 protein for plexiform ameloblastoma (magnification = 200 ×).
See this image and copyright information in PMC

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