doi: 10.1007/BF01012540.
A technique for quantitating enzyme histochemistry in adjuvant arthritic joints. I. Alkaline phosphatase
- PMID: 389890
- DOI: 10.1007/BF01012540
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A technique for quantitating enzyme histochemistry in adjuvant arthritic joints. I. Alkaline phosphatase
Histochem J.
1979 Sep.
Abstract
This paper establishes a quantitative technique for measuring the percentage of enzyme-reactive cells found in adjuvant arthritic articular cartilage, synovial membrane and bone marrow. Using alkaline phosphatase histochemistry and a recently-developed method of handling hard tissues, the technique is validated, the inherent variabilities determined and the existence of intra-articular lesions established. The technique now allows for a precise in situ evaluation of adjuvant arthritic drug inhibition by measuring enzyme-reactive cell alterations within the joint tissue most affected by the arthritis.
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