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. 1979 Sep;11(5):573-85.
doi: 10.1007/BF01012540.

A technique for quantitating enzyme histochemistry in adjuvant arthritic joints. I. Alkaline phosphatase

F R Nusbickel

A technique for quantitating enzyme histochemistry in adjuvant arthritic joints. I. Alkaline phosphatase

F R Nusbickel. Histochem J. 1979 Sep.

Abstract

This paper establishes a quantitative technique for measuring the percentage of enzyme-reactive cells found in adjuvant arthritic articular cartilage, synovial membrane and bone marrow. Using alkaline phosphatase histochemistry and a recently-developed method of handling hard tissues, the technique is validated, the inherent variabilities determined and the existence of intra-articular lesions established. The technique now allows for a precise in situ evaluation of adjuvant arthritic drug inhibition by measuring enzyme-reactive cell alterations within the joint tissue most affected by the arthritis.

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References

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