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Editorial
. 2024 May 20;86(7):3824-3826.
doi: 10.1097/MS9.0000000000002207. eCollection 2024 Jul.

Transforming the management of chronic kidney disease-associated anemia using daprodustat

Ifrah I Raza  1 , Shaheera Younus  1 , Hiba Azhar  1 , Hareer Fatima  1 , Zainab Anwar  1 , Asma A Farah  2 , Hussain Sohail Rangwala  1
Affiliations
Editorial

Transforming the management of chronic kidney disease-associated anemia using daprodustat

Ifrah I Raza et al. Ann Med Surg (Lond). .
No abstract available

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Conflict of interest statement

The authors declare no potential conflicts of interest concerning the research, authorship, and/or publication of this article.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Figures

Figure 1
Figure 1
Mechanism of action of daprodustat. Under normal conditions, rapid degradation of HIF1-α occurs through the action of the HIF-PH enzyme (as indicated by the red arrows). However, during hypoxia, the HIF-PH enzyme is suppressed, which leads to upregulation of the EPO gene by the formation of the HIF1 α-β heterodimer (as indicated by the black arrows). Daprodustat has direct inhibitory effects on the HIF-PH enzyme.
See this image and copyright information in PMC

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