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. 2024 Jul 11;7(7):CD015555.
doi: 10.1002/14651858.CD015555.

Shorter versus longer duration antibiotic regimens for treatment of culture-positive neonatal sepsis

Alexandra A Legge  1 , Jennifer L Middleton  1 , Michelle Fiander  2 , Jane Cracknell  3 , David A Osborn  1   4 , Adrienne Gordon  1   5   6
Affiliations

Shorter versus longer duration antibiotic regimens for treatment of culture-positive neonatal sepsis

Alexandra A Legge et al. Cochrane Database Syst Rev. .

Abstract

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the safety and effectiveness of shorter versus longer duration antibiotic regimens for the treatment of culture-positive neonatal sepsis with or without meningitis.

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Conflict of interest statement

AL: none.

AG: is a member and past chair of the Sepsis Prevention quality improvement group in New South Wales, Australia.

DO: is a Senior Editor for Cochrane Neonatal; however, he did not participate in the editorial process for this protocol.

JM: is employed by a non‐profit organisation, Royal Prince Alfred Hospital, NSW Health, as a research co‐ordinator. Royal Prince Alfred Hospital, NSW Health, does not have an interest in the topic of interest.

MF: is a Managing Editor and Information Specialist for Cochrane Neonatal; however, she did not participate in the editorial process for this protocol.

JC: is a Managing Editor for Cochrane Neonatal; however, she did not participate in the editorial process for this protocol.

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References

Additional references

Al‐Taiar 2013
    1. Al-Taiar A, Hammoud MS, Cuiqing L, Lee JK, Lui KM, Nakwan N, et al. Neonatal infections in China, Malaysia, Hong Kong and Thailand. Archives of Disease in Childhood. Fetal and Neonatal Edition 2013;98(3):F249-55. [DOI: 10.1136/archdischild-2012-301767] [PMID: ] - DOI - PubMed
Alm 2008
    1. Alm B, Erdes L, Mollborg P, Pettersson R, Norvenius SG, Aberg N, et al. Neonatal antibiotic treatment is a risk factor for early wheezing. Pediatrics 2008;121(4):697-702. [DOI: 10.1542/peds.2007-1232] [PMID: ] - DOI - PubMed
Anderson 1990
    1. Anderson SG, Gilbert GL. Neonatal gram negative meningitis: a 10-year review, with reference to outcome and relapse of infection. Journal of Paediatrics and Child Health 1990;26(4):212-6. [DOI: 10.1111/j.1440-1754.1990.tb02432.x] [PMID: ] - DOI - PubMed
Antimicrobial Resistance Collaborators 2022
    1. Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 2022;399(10325):629-55. [DOI: 10.1016/S0140-6736(21)02724-0] [PMID: ] - DOI - PMC - PubMed
ANZNN 2023
    1. Australian and New Zealand Neonatal Network. ANZNN 2023 Data Dictionary. Sydney, Australia, 2022. anznn.net/dataresources/datadictionaries (accessed prior to 17 June 2024).
Bakhuizen 2014
    1. Bakhuizen SE, Haan TR, Teune MJ, Wassenaer-Leemhuis AG, Heyden JL, Ham DP, et al. Meta-analysis shows that infants who have suffered neonatal sepsis face an increased risk of mortality and severe complications. Acta Paediatrica 2014;103(12):1211-8. [DOI: 10.1111/apa.12764] [PMID: ] - DOI - PubMed
Bell 1978
    1. Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L, et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Annals of Surgery 1978;187(1):1-7. [DOI: 10.1097/00000658-197801000-00001] [PMID: ] - DOI - PMC - PubMed
Benitz 1999
    1. Benitz WE, Gould JB, Druzin ML. Antimicrobial prevention of early-onset group B streptococcal sepsis: estimates of risk reduction based on a critical literature review. Pediatrics 1999;103(6):e78. [PMID: ] - PubMed
Benjamin 2006
    1. Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, et al, National Institute of Child Health, Human Development Neonatal Research Network. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics 2006;117(1):84-92. [DOI: 10.1542/peds.2004-2292] [PMID: ] - DOI - PubMed
Boghossian 2013
    1. Boghossian NS, Page GP, Bell EF, Stoll BJ, Murray JC, Cotten CM, et al, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network. Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births. Journal of Pediatrics 2013;162(6):1120-4, 1124 e1. [DOI: 10.1016/j.jpeds.2012.11.089] [PMID: ] - DOI - PMC - PubMed
Cailes 2018
    1. Cailes B, Kortsalioudaki C, Buttery J, Pattnayak S, Greenough A, Matthes J, et al, neonIN network. Epidemiology of UK neonatal infections: the neonIN infection surveillance network. Archives of Disease in Childhood. Fetal and Neonatal Edition 2018;103(6):F547-53. [DOI: 10.1136/archdischild-2017-313203] [PMID: ] - DOI - PubMed
Camacho‐Gonzalez 2013
    1. Camacho-Gonzalez A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatric Clinics of North America 2013;60(2):367-89. [DOI: 10.1016/j.pcl.2012.12.003] [PMID: ] - DOI - PMC - PubMed
Campbell 1992
    1. Campbell JR, Diacovo T, Baker CJ. Serratia marcescens meningitis in neonates. Pediatric Infectious Disease Journal 1992;11(10):881-6. [DOI: 10.1097/00006454-199210000-00015] [PMID: ] - DOI - PubMed
Campbell 2020
    1. Campbell M, McKenzie JE, Sowden A, Katikireddi SV, Brennan SE, Ellis S, et al. Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. BMJ 2020;368:l6890. [DOI: 10.1136/bmj.l6890] [PMID: ] - DOI - PMC - PubMed
Clark 2006
    1. Clark RH, Bloom BT, Spitzer AR, Gerstmann DR. Reported medication use in the neonatal intensive care unit: data from a large national data set. Pediatrics 2006;117(6):1979-87. [DOI: 10.1542/peds.2005-1707] [PMID: ] - DOI - PubMed
Coggins 2023
    1. Coggins SA, Edwards EM, Flannery DD, Gerber JS, Horbar JD, Puopolo KM. Serratia infection epidemiology among very preterm infants in the neonatal intensive care unit. Pediatric Infectious Disease Journal 2023;42(2):152-8. [DOI: 10.1097/INF.0000000000003736] [PMID: ] - DOI - PMC - PubMed
Connell 2007
    1. Connell TG, Rele M, Cowley D, Buttery JP, Curtis N. How reliable is a negative blood culture result? Volume of blood submitted for culture in routine practice in a children's hospital. Pediatrics 2007;119(5):891-6. [DOI: 10.1542/peds.2006-0440] [PMID: ] - DOI - PubMed
Cordero 2003
    1. Cordero L, Ayers LW. Duration of empiric antibiotics for suspected early-onset sepsis in extremely low birth weight infants. Infection Control and Hospital Epidemiology 2003;24(9):662-6. [DOI: 10.1086/502270] [PMID: ] - DOI - PubMed
Cortese 2016
    1. Cortese F, Scicchitano P, Gesualdo M, Filaninno A, De Giorgi E, Schettini F, et al. Early and late infections in newborns: where do we stand? A review. Pediatrics and Neonatology 2016;57(4):265-73. [DOI: 10.1016/j.pedneo.2015.09.007] [PMID: ] - DOI - PubMed
Cotten 2006
    1. Cotten CM, McDonald S, Stoll B, Goldberg RN, Poole K, Benjamin DK Jr, National Institute for Child Health, Human Development Neonatal Research Network. The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics 2006;118(2):717-22. [DOI: 10.1542/peds.2005-2677] [PMID: ] - DOI - PubMed
Cotten 2009
    1. Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sanchez PJ, et al, NICHD Neonatal Research Network. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics 2009;123(1):58-66. [DOI: 10.1542/peds.2007-3423] [PMID: ] - DOI - PMC - PubMed
Covidence [Computer program]
    1. Covidence. Version accessed 8 September 2023. Melbourne, Australia: Veritas Health Innovation. Available at covidence.org.
de Man 2000
    1. Man P, Verhoeven BA, Verbrugh HA, Vos MC, den Anker JN. An antibiotic policy to prevent emergence of resistant bacilli. Lancet 2000;355(9208):973-8. [DOI: 10.1016/s0140-6736(00)90015-1] [PMID: ] - DOI - PubMed
Deeks 2022
    1. Deeks JJ, Higgins JP, Altman DG. Chapter 10: Analysing data and undertaking meta-analyses. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022. Available from training.cochrane.org/handbook/archive/v6.3.
Dong 2015
    1. Dong Y, Speer CP. Late-onset neonatal sepsis: recent developments. Archives of Disease in Childhood. Fetal and Neonatal Edition 2015;100(3):F257-63. [DOI: 10.1136/archdischild-2014-306213] [PMID: ] - DOI - PMC - PubMed
Egger 1997
    1. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315(7109):629-34. [DOI: 10.1136/bmj.315.7109.629] [PMID: ] - DOI - PMC - PubMed
El‐Naggar 2019
    1. El-Naggar W, Afifi J, McMillan D, Toye J, Ting J, Yoon EW, et al, Canadian Neonatal Network Investigators II. Epidemiology of meningitis in Canadian neonatal intensive care units. Pediatric Infectious Disease Journal 2019;38(5):476-80. [DOI: 10.1097/INF.0000000000002247] [PMID: ] - DOI - PubMed
Endnote [Computer program]
    1. Endnote. Version X9. Philadelphia (PA): Clarivate, 2023. Available at https://endnote.com/.
EPOC
    1. Cochrane Effective Practice and Organisation of Care (EPOC). Cochrane Effective Practice and Organisation of Care Review Group. Data collection check list. methods.cochrane.org/sites/methods.cochrane.org.bias/files/uploads/EPOC%... (accessed 8 September 2023).
Flannery 2022
    1. Flannery DD, Edwards EM, Coggins SA, Horbar JD, Puopolo KM. Late-onset sepsis among very preterm infants. Pediatrics 2022;150(6):e2022058813. [DOI: 10.1542/peds.2022-058813] [PMID: ] - DOI - PMC - PubMed
Fleischmann 2021
    1. Fleischmann C, Reichert F, Cassini A, Horner R, Harder T, Markwart R, et al. Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis. Archives of Disease in Childhood 2021;106(8):745-52. [DOI: 10.1136/archdischild-2020-320217] [PMID: ] - DOI - PMC - PubMed
Fleischmann‐Struzek 2018
    1. Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respiratory Medicine 2018;6(3):223-30. [DOI: 10.1016/S2213-2600(18)30063-8] [PMID: ] - DOI - PubMed
Gkentzi 2019
    1. Gkentzi D, Dimitriou G. Antimicrobial stewardship in the neonatal intensive care unit: an update. Current Pediatric Reviews 2019;15(1):47-52. [DOI: 10.2174/1573396315666190118101953] [PMID: ] - DOI - PMC - PubMed
Gordon 2006
    1. Gordon A, Isaacs D. Late onset neonatal gram-negative bacillary infection in Australia and New Zealand: 1992–2002. Pediatric Infectious Disease Journal 2006;25(1):25-9. [DOI: 10.1097/01.inf.0000195628.35980.2e] [PMID: ] - DOI - PubMed
GRADEpro GDT [Computer program]
    1. GRADEpro GDT. Version accessed 8 September 2023. Hamilton (ON): McMaster University (developed by Evidence Prime). Available at https://gradepro.org.
Hammoud 2012
    1. Hammoud MS, Al-Taiar A, Thalib L, Al-Sweih N, Pathan S, Isaacs D. Incidence, aetiology and resistance of late-onset neonatal sepsis: a five-year prospective study. Journal of Paediatrics and Child Health 2012;48(7):604-9. [DOI: 10.1111/j.1440-1754.2012.02432.x] [PMID: ] - DOI - PubMed
Higgins 2011
    1. Higgins JP, Altman DG, Sterne JA. Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Churchill R, Chandler J, Cumpston MS, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). Cochrane, 2011. Available from training.cochrane.org/handbook/archive/v5.1/.
Higgins 2022a
    1. Higgins JP, Li T, Deeks JJ. Chapter 6: Choosing effect measures and computing estimates of effect. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022. Available from training.cochrane.org/handbook/archive/v6.3.
Isaacs 1995
    1. Isaacs D, Barfield CP, Grimwood K, McPhee AJ, Minutillo C, Tudehope DI. Systemic bacterial and fungal infections in infants in Australian neonatal units. Medical Journal of Australia 1995;162(4):198-201. [DOI: 10.5694/j.1326-5377.1995.tb126024.x] [PMID: ] - DOI - PubMed
Isaacs 1996
    1. Isaacs D, Barfield C, Clothier T, Darlow B, Diplock R, Ehrlich J, et al. Late-onset infections of infants in neonatal units. Journal of Paediatrics and Child Health 1996;32(2):158-61. [DOI: 10.1111/j.1440-1754.1996.tb00914.x] [PMID: ] - DOI - PubMed
Isaacs 2006
    1. Isaacs D. Unnatural selection: reducing antibiotic resistance in neonatal units. Archives of Disease in Childhood. Fetal and Neonatal Edition 2006;91(1):F72-4. [DOI: 10.1136/adc.2005.074963] [PMID: ] - DOI - PMC - PubMed
Isaacs 2014
    1. Isaacs D. Evidence-Based Neonatal Infections. Hoboken (NJ): John Wiley & Sons, 2014. [PRINT ISBN: 9780470654606]
Jenkins 2017
    1. Jenkins A, Geldenhuys C, Bekker A, Dramowski A. Central-line-associated bloodstream infections in a resource-limited South African neonatal intensive care unit. South African Medical Journal 2017;107(9):758-62. [DOI: 10.7196/SAMJ.2017.v107i9.12124] [PMID: ] - DOI - PubMed
Kayange 2010
    1. Kayange N, Kamugisha E, Mwizamholya DL, Jeremiah S, Mshana SE. Predictors of positive blood culture and deaths among neonates with suspected neonatal sepsis in a tertiary hospital, Mwanza-Tanzania. BMC Pediatrics 2010;10:39. [DOI: 10.1186/1471-2431-10-39] [PMID: ] - DOI - PMC - PubMed
Korang 2021a
    1. Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, et al. Antibiotic regimens for early-onset neonatal sepsis. Cochrane Database of Systematic Reviews 2021, Issue 5. Art. No: CD013837. [DOI: 10.1002/14651858.CD013837.pub2] - DOI - PMC - PubMed
Korang 2021b
    1. Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, et al. Antibiotic regimens for late-onset neonatal sepsis. Cochrane Database of Systematic Reviews 2021, Issue 5. Art. No: CD013836. [DOI: 10.1002/14651858.CD013836.pub2] - DOI - PMC - PubMed
Kuppala 2011
    1. Kuppala VS, Meinzen-Derr J, Morrow AL, Schibler KR. Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants. Journal of Pediatrics 2011;159(5):720-5. [DOI: 10.1016/j.jpeds.2011.05.033] [PMID: ] - DOI - PMC - PubMed
Lawn 2014
    1. Lawn JE, Blencowe H, Oza S, You D, Lee AC, Waiswa P, et al, Lancet Every Newborn Study Group. Every newborn: progress, priorities, and potential beyond survival. Lancet 2014;384(9938):189-205. [DOI: 10.1016/S0140-6736(14)60496-7] [PMID: ] - DOI - PubMed
Laxminarayan 2016
    1. Laxminarayan R, Matsoso P, Pant S, Brower C, Røttingen JA, Klugman K, et al. Access to effective antimicrobials: a worldwide challenge. Lancet 2016;387(10014):168-75. [DOI: 10.1016/S0140-6736(15)00474-2] [PMID: ] - DOI - PubMed
Leal 2012
    1. Leal YA, Alvarez-Nemegyei J, Velazquez JR, Rosado-Quiab U, Diego-Rodriguez N, Paz-Baeza E, et al. Risk factors and prognosis for neonatal sepsis in southeastern Mexico: analysis of a four-year historic cohort follow-up. BMC Pregnancy and Childbirth 2012;12:48. [DOI: 10.1186/1471-2393-12-48] [PMID: ] - DOI - PMC - PubMed
Lee 2013
    1. Lee JH, Hornik CP, Benjamin DK Jr, Herring AH, Clark RH, Cohen-Wolkowiez M, et al. Risk factors for invasive candidiasis in infants >1500 g birth weight. Pediatric Infectious Disease Journal 2013;32(3):222-6. [DOI: 10.1097/INF.0b013e3182769603] [PMID: ] - DOI - PMC - PubMed
Legge 2023
    1. Legge A, Gordon A, Middleton JL, Fiander M, Cracknell J, Osborn DA. Shorter versus longer duration antibiotic regimens for treatment of suspected neonatal sepsis. Protocol under development. To be published in the Cochrane Database of Systematic Reviews: https://www.cochrane.library.com.
Linder 2013
    1. Linder N, Lubin D, Hernandez A, Amit L, Ashkenazi S. Duration of vancomycin treatment for coagulase-negative Staphylococcus sepsis in very low birth weight infants. British Journal of Clinical Pharmacology 2013;76(1):58-64. [DOI: 10.1111/bcp.12053] [PMID: ] - DOI - PMC - PubMed
Liu 2016
    1. Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, et al. Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet 2016;388(10063):3027-35. [DOI: 10.1016/S0140-6736(16)31593-8] [PMID: ] - DOI - PMC - PubMed
Makhoul 2002
    1. Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B. Epidemiological, clinical, and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: a national survey. Pediatrics 2002;109(1):34-9. [DOI: 10.1542/peds.109.1.34] [PMID: ] - DOI - PubMed
Manan 2016
    1. Manan MM, Ibrahim NA, Aziz NA, Zulkifly HH, Al-Worafi YM, Long CM. Empirical use of antibiotic therapy in the prevention of early onset sepsis in neonates: a pilot study. Archives of Medical Science 2016;12(3):603-13. [DOI: 10.5114/aoms.2015.51208] [PMID: ] - DOI - PMC - PubMed
Marshall 2018
    1. Marshall IJ, Noel-Storr AH, Kuiper J, Thomas J, Wallace BC. Machine learning for identifying randomized controlled trials: an evaluation and practitioner's guide. Research Synthesis Methods 2018;9(4):602-14. [DOI: 10.1002/jrsm.1287] [PMID: ] - DOI - PMC - PubMed
McKenzie 2023
    1. McKenzie JE, Brennan SE. Chapter 12: Synthesizing and presenting findings using other methods. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.4 (updated August 2023). Cochrane, 2023. Available from training.cochrane.org/handbook.
McMullan 2016
    1. McMullan BJ, Andresen D, Blyth CC, Avent ML, Bowen AC, Britton PN, et al, ANZPID-ASAP group. Antibiotic duration and timing of the switch from intravenous to oral route for bacterial infections in children: systematic review and guidelines. Lancet. Infectious Diseases 2016;16(8):e139-52. [DOI: 10.1016/S1473-3099(16)30024-X] [PMID: ] - DOI - PubMed
Milton 2022
    1. Milton R, Gillespie D, Dyer C, Taiyari K, Carvalho MJ, Thomson K, et al. Neonatal sepsis and mortality in low-income and middle-income countries from a facility-based birth cohort: an international multisite prospective observational study. Lancet Global Health 2022;10(5):e661-72. [DOI: 10.1016/S2214-109X(22)00043-2] [PMID: ] - DOI - PMC - PubMed
Mukhopadhyay 2019
    1. Mukhopadhyay S, Wade KC, Puopolo KM. Drugs for the prevention and treatment of sepsis in the newborn. Clinics in Perinatology 2019;46(2):327-47. [DOI: 10.1016/j.clp.2019.02.012] [PMID: ] - DOI - PMC - PubMed
Mukhopadhyay 2021
    1. Mukhopadhyay S, Puopolo KM, Hansen NI, Lorch SA, DeMauro SB, Greenberg RG, et al, NICHD Neonatal Research Network. Neurodevelopmental outcomes following neonatal late-onset sepsis and blood culture negative conditions. Archives of Disease in Childhood. Fetal and Neonatal Edition 2021;106(5):467-73. [PMID: ] - PMC - PubMed
Murki 2010
    1. Murki S, Jonnala S, Mohammed F, Reddy A. Restriction of cephalosporins and control of extended spectrum beta-lactamase producing gram negative bacteria in a neonatal intensive care unit. Indian Pediatrics 2010;47(9):785-8. [DOI: 10.1007/s13312-010-0118-y] [PMID: ] - DOI - PubMed
NICE 2021
    1. National Institute for Health and Care Excellence. Neonatal infection: antibiotics for prevention and treatment. 2021. Available from www.nice.org.uk/guidance/ng195. - PubMed
Noel‐Storr 2020
    1. Noel-Storr AH, Dooley G, Wisniewski S, Glanville J, Thomas J, Cox S, et al. Cochrane Centralised Search Service showed high sensitivity identifying randomised controlled trials: a retrospective analysis. Journal of Clinical Epidemiology 2020;127:142-50. [DOI: 10.1016/j.jclinepi.2020.08.008] [PMID: ] - DOI - PubMed
Noel‐Storr 2021
    1. Noel-Storr AH, Dooley G, Elliott J, Steele E, Shemilt I, Mavergames C, et al. An evaluation of Cochrane Crowd found that crowdsourcing produced accurate results in identifying randomised trials. Journal of Clinical Epidemiology 2021;4356(21):130-9. [DOI: 10.1016/j.jclinepi.2021.01.006] [PMID: ] - DOI - PubMed
O'Grady 2011
    1. O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, et al, Healthcare Infection Control Practices Advisory Committee. Guidelines for the prevention of intravascular catheter-related infections. American Journal of Infection Control 2011;39(4 Suppl 1):S1-34. [DOI: 10.1016/j.ajic.2011.01.003] [PMID: ] - DOI - PubMed
Okascharoen 2005
    1. Oskascharoen C, Sirinavin S, Thakkinstian, Kitayaporn D, Supapanachart S. A bedside prediction-scoring model for late-onset neonatal sepsis. Journal of Perinatology 2005;25(12):778-83. [PMID: ] - PubMed
Okascharoen 2007
    1. Okascharoen C, Hui C, Cairnie J, Morris AM, Kirpalani H. External validation of bedside prediction score for diagnosis of late-onset neonatal sepsis. Journal of Perinatology 2007;27(8):496-501. [PMID: ] - PubMed
Oosterloo 2018
    1. Oosterloo BC, Elburg RM, Rutten NB, Bunkers CM, Crijns CE, Meijssen CB, et al. Wheezing and infantile colic are associated with neonatal antibiotic treatment. Pediatric Allergy and Immunology 2018;29(2):151-8. [DOI: 10.1111/pai.12857] [PMID: ] - DOI - PubMed
Page 2021a
    1. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71. [DOI: 10.1136/bmj.n71] - DOI - PMC - PubMed
Page 2021b
    1. Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ 2021;372:n160. [DOI: 10.1136/bmj.n160] - DOI - PMC - PubMed
Papile 1978
    1. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. Journal of Pediatrics 1978;92(4):529-34. [PMID: ] - PubMed
Park 2014
    1. Park SH, Milstone AM, Diener-West M, Nussenblatt V, Cosgrove SE, Tamma PD. Short versus prolonged courses of antibiotic therapy for children with uncomplicated gram-negative bacteraemia. Journal of Antimicrobial Chemotherapy 2014;69(3):779-85. [DOI: 10.1093/jac/dkt424] [PMID: ] - DOI - PubMed
Perin 2022
    1. Perin J, Mulick A, Yeung D, Villavicencio F, Lopez G, Strong KL, et al. Global, regional, and national causes of under-5 mortality in 2000-19: an updated systematic analysis with implications for the sustainable development goals. Lancet. Child and Adolescent Health 2022;6(2):106-15. [DOI: 10.1016/S2352-4642(21)00311-4] [PMID: ] - DOI - PMC - PubMed
Pittard 1976
    1. Pittard WB, Thullen JD, Fanaroff AA. Neonatal septic arthritis. Journal of Pediatrics 1976;68(4):621-4. [DOI: 10.1016/s0022-3476(76)80022-4] [PMID: ] - DOI - PubMed
Polin 2012
    1. Polin RA, Committee on Fetus and Newborn. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics 2012;129(5):1006-15. [PMID: ] - PubMed
RevMan 2024 [Computer program]
    1. Review Manager (RevMan). Version 7.7.2. The Cochrane Collaboration, 2024. Available at https://revman.cochrane.org.
Reyman 2022
    1. Reyman M, Houten MA, Watson RL, Chu ML, Arp K, Waal WJ, et al. Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial. Nature Communications 2022;13(1):893. [DOI: 10.1038/s41467-022-28525-z] [PMID: ] - DOI - PMC - PubMed
Roine 2000
    1. Roine I, Ledermann W, Foncea LM, Banfi A, Cohen J, Peltola H. Randomized trial of four vs. seven days of ceftriaxone treatment for bacterial meningitis in children with rapid initial recovery. Pediatric Infectious Disease Journal 2000;19(3):219-22. [DOI: 10.1097/00006454-200003000-00009] [PMID: ] - DOI - PubMed
Rosenthal 2009
    1. Rosenthal VD. Central line-associated bloodstream infections in limited-resource countries: a review of the literature. Clinical Infectious Diseases 2009;49(12):1899-907. [DOI: ] [PMID: 10.1086/648439] - DOI - PubMed
S4M
    1. Cochrane. Screen4Me. https://training.cochrane.org/online-learning/good-practice-resources-co... (accessed 11 September 2023).
Sands 2022
    1. Sands K, Spiller OB, Thomson K, Portal EA, Iregbu KC, Walsh TR. Early-onset neonatal sepsis in low- and middle-income countries: current challenges and future opportunities. Infection and Drug Resistance 2022;15:933-46. [DOI: 10.2147/IDR.S294156] [PMID: ] - DOI - PMC - PubMed
Schelonka 1996
    1. Schelonka RL, Chai MK, Yoder BA, Hensley D, Brockett RM, Ascher DP. Volume of blood required to detect common neonatal pathogens. Journal of Pediatrics 1996;129(2):275-8. [DOI: 10.1016/s0022-3476(96)70254-8] [PMID: ] - DOI - PubMed
Schlapbach 2011
    1. Shlapbach LJ, Aebischer M, Adams M, Natalucci G, Bonhoeffer J, Latzin P, et al, Swiss Neonatal Network and Follow-Up Group. Impact of sepsis on neurodevelopmental outcome in a Swiss national cohort of extremely premature infants. Pediatrics 2011;128(2):e348-57. [DOI: 10.1542/peds.2010-3338] [PMID: ] - DOI - PubMed
Schrag 2016
    1. Schrag SJ, Farley MM, Petit S, Reingold A, Weston EJ, Pondo T, et al. Epidemiology of invasive early-onset neonatal sepsis, 2005 to 2014. Pediatrics 2016;138(6):e20162013. [DOI: 10.1542/peds.2016-2013] [PMID: ] - DOI - PubMed
Schünemann 2013
    1. Schünemann H, Brożek J, Guyatt G, Oxman A, editor(s). Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach (updated October 2013). GRADE Working Group, 2013. Available from https://gdt.gradepro.org/app/handbook/handbook.html.
Schünemann 2022
    1. Schünemann HJ, Vist GE, Higgins JP, Santesso N, Deeks JJ, Glasziou P, et al. Chapter 15: Interpreting results and drawing conclusions. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Available from training.cochrane.org/handbook/archive/v6.3.
Shane 2017
    1. Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet 2017;390(10104):1770-80. [DOI: 10.1016/S0140-6736(17)31002-4] [PMID: ] - DOI - PubMed
Singer 2016
    1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016;315(8):801-10. [DOI: 10.1001/jama.2016.0287] [PMID: ] - DOI - PMC - PubMed
Stark 2022
    1. Stark A, Smith PB, Hornik CP, Zimmerman KO, Hornik CD, Pradeep S, et al. Medication use in the neonatal intensive care unit and changes from 2010 to 2018. Journal of Pediatrics 2022;240:66-71.e4. [DOI: 10.1016/j.jpeds.2021.08.075] [PMID: ] - DOI - PMC - PubMed
Stoll 2002
    1. Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002;110(2 Pt 1):285-91. [DOI: 10.1542/peds.110.2.285] [PMID: ] - DOI - PubMed
Stoll 2011
    1. Stoll BJ, Hansen NI, Sánchez PJ, Faix RG, Poindexter BB, Meurs KP, et al, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. Pediatrics 2011;127(5):817-26. [PMID: 10.1542/peds.2010-2217] [PMID: ] - DOI - PMC - PubMed
Thaver 2009
    1. Thaver D, Zaidi AK. Burden of neonatal infections in developing countries: a review of evidence from community-based studies. Pediatric Infectious Disease Journal 2009;28(1 Suppl):S3-9. [DOI: 10.1097/INF.0b013e3181958755] [PMID: ] - DOI - PubMed
Thomas 2021
    1. Thomas J, McDonald S, Noel-Storr AH, Shemilt I, Elliott J, Mavergames C, et al. Machine learning reduces workload with minimal risk of missing studies: development and evaluation of an RCT classifier for Cochrane reviews. Journal of Clinical Epidemiology 2021;133:140-51. [DOI: 10.1016/j.jclinepi.2020.11.003] [PMID: ] - DOI - PMC - PubMed
Thomas 2022
    1. Thomas R, Ondongo-Ezhet C, Motsoaledi N, Sharland M, Clements M, Velaphi S. Incidence and all-cause mortality rates in neonates infected with carbapenem resistant organisms. Frontiers in Tropical Diseases 2022;3:832011. [DOI: 10.3389/fitd.2022.832011] [URL: https://www.frontiersin.org/articles/10.3389/fitd.2022.832011/full] - DOI
Ting 2016
    1. Ting JY, Synnes A, Roberts A, Deshpandey A, Dow K, Yoon EW, et al, Canadian Neonatal Network Investigators. Association between antibiotic use and neonatal mortality and morbidities in very low-birth-weight infants without culture-proven sepsis or necrotizing enterocolitis. JAMA Pediatrics 2016;170(12):1181-7. [DOI: 10.1001/jamapediatrics.2016.2132] [PMID: ] - DOI - PubMed
Tsai 2014a
    1. Tsai MH, Hsu JF, Chu SM, Lien R, Huang HR, Chiang MC, et al. Incidence, clinical characteristics and risk factors for adverse outcome in neonates with late-onset sepsis. Pediatric Infectious Diseases Journal 2014;33(1):e7-13. [DOI: 10.1097/INF.0b013e3182a72ee0] [PMID: ] - DOI - PubMed
Tsai 2014b
    1. Tsai MH, Chu SM, Lee CW, Hsu JF, Huang HR, Chiang MC, et al. Recurrent late-onset sepsis in the neonatal intensive care unit: incidence, clinical characteristics and risk factors. Clinical Microbiology and Infection 2014;20(11):O928-35. [DOI: 10.1111/1469-0691.12661] [PMID: ] - DOI - PubMed
Vergnano 2005
    1. Vergnano S, Sharland M, Kazembe P, Mwansambo C, Heath PT. Neonatal sepsis: an international perspective. Archives of Disease in Childhood. Fetal and Neonatal Edition 2005;90(3):F220-4. [DOI: 10.1136/adc.2002.022863] [PMID: ] - DOI - PMC - PubMed
Vergnano 2011
    1. Vergnano S, Menson E, Kennea N, Embleton N, Russell AB, Watts T, et al. Neonatal infections in England: the NeonIN surveillance network. Archives of Disease in Childhood. Fetal and Neonatal Edition 2011;96(1):F9-14. [DOI: 10.1136/adc.2009.178798] [PMID: ] - DOI - PubMed
Viswanathan 2012
    1. Viswanathan R, Singh AK, Basu S, Chatterjee S, Sardar S, Isaacs D. Multi-drug resistant gram negative bacilli causing early neonatal sepsis in India. Archives of Disease in Childhood. Fetal and Neonatal Edition 2012;97(3):F182-7. [PMID: 10.1136/archdischild-2011-300097] [PMID: ] - DOI - PubMed
Wu 2012
    1. Wu J, Mu D. Vascular catheter-related complications in newborns. Journal of Paediatrics and Child Health 2012;48(2):E91-5. [DOI: 10.1111/j.1440-1754.2010.01934.x] [PMID: ] - DOI - PubMed
Wynn 2016
    1. Wynn JL. Defining neonatal sepsis. Current Opinion in Pediatrics 2016;28(2):135-40. [DOI: 10.1097/MOP.0000000000000315] [PMID: ] - DOI - PMC - PubMed
Zaidi 2009
    1. Zaidi AK, Thaver D, Ali SA, Khan TA. Pathogens associated with sepsis in newborns and young infants in developing countries. Pediatric Infectious Disease Journal 2009;28(1 Suppl):S10-8. [DOI: 10.1097/INF.0b013e3181958769] [PMID: ] - DOI - PubMed
Zaidi 2011
    1. Zaidi AK, Ganatra HA, Syed S, Cousens S, Lee AC, Black, et al. Effect of case management on neonatal mortality due to sepsis and pneumonia. BMC Public Health 2011;11(Suppl 3):S13. [DOI: 10.1186/1471-2458-11-S3-S13] [PMID: ] - DOI - PMC - PubMed
Zipursky 2019
    1. Zipursky AR, Yoon EW, Emberley J, Bertelle V, Kanungo J, Lee SK, et al, Canadian Neonatal Network Investigators. Central line-associated blood stream infections and non-central line-associated blood stream infections surveillance in Canadian tertiary care neonatal intensive care units. Journal of Pediatrics 2019;208:176-82.e. [DOI: 10.1016/j.jpeds.2018.12.011] [PMID: ] - DOI - PubMed

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