Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jan 1;111(1):1469-1472.
doi: 10.1097/JS9.0000000000001908.

Effect of remimazolam besylate vs propofol on incidence of postoperative delirium in older patients undergoing hip surgery: a randomized noninferiority trial

Collaborators, Affiliations

Effect of remimazolam besylate vs propofol on incidence of postoperative delirium in older patients undergoing hip surgery: a randomized noninferiority trial

Pan-Pan Fang et al. Int J Surg. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

None of the authors report having a conflict of interest of this study.

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Figures

Figure 1
Figure 1
Flow Diagram for the REMPPOD trial. The flow chart shows this multicenter, randomized trial conducted on elderly patients undergoing hip surgery. Group R, patients received remimazolam besylate for induction and maintenance of general anesthesia. Group P, patients received propofol for induction and maintenance of general anesthesia.
Figure 2
Figure 2
Kaplan–Meier curve showing intention-to-treat analysis of cumulative incidence of delirium during postoperative days 1 to 3 between two groups. Group R, patients received remimazolam besylate for induction and maintenance of general anesthesia. Group P, patients received propofol for induction and maintenance of general anesthesia.

References

    1. Inouye SK, Westendorp RGJ, Saczynski JS. Delirium in elderly people. Lancet 2014;383:911–922. - PMC - PubMed
    1. Schuttler J, Eisenried A, Lerch M, et al. . Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: part I. pharmacokinetics and clinical pharmacodynamics. Anaesthesiology 2020;132:636–651. - PubMed
    1. Sneyd JR, Rigby-Jones AE. Remimazolam for anaesthesia or sedation. Curr Opin Anaesthesiol 2020;33:506–511. - PubMed
    1. Keam SJ. Remimazolam: first approval. Drugs 2020;80:625–633. - PubMed
    1. Lohmer LL, Schippers F, Petersen KU, et al. . Time-to-event modeling for remimazolam for the indication of induction and maintenance of general anaesthesia. J Clin Pharmacol 2020;60:505–514. - PMC - PubMed

LinkOut - more resources