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Multicenter Study
. 2024 Oct 15;79(4):1034-1038.
doi: 10.1093/cid/ciae367.

Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India

Senbagavalli Prakash Babu  1 , Komala Ezhumalai  1 , Kalaivani Raghupathy  1 , Meagan Karoly  2 , Palanivel Chinnakali  1 , Nikhil Gupte  3   4 , Mandar Paradkar  3   4 , Arutselvi Devarajan  5 , Mythili Dhanasekaran  5 , Kannan Thiruvengadam  6 , Madolyn Rose Dauphinais  2 , Akshay N Gupte  2 , Shrivijay Balayogendra Shivakumar  4 , Balamugesh Thangakunam  7 , Devasahayam Jesudas Christopher  7 , Vijay Viswanathan  5 , Vidya Mave  3   4 , Sanjay Gaikwad  3 , Aarti Kinikar  3 , Hardy Kornfeld  8 , C Robert Horsburgh  2 , Padmapriyadarsini Chandrasekaran  6 , Natasha S Hochberg  2 , Padmini Salgame  9 , Amita Gupta  10 , Gautam Roy  1 , Jerrold Ellner  9 , Pranay Sinha  2 , Sonali Sarkar  1
Affiliations
Multicenter Study

Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India

Senbagavalli Prakash Babu et al. Clin Infect Dis. .

Abstract

In this prospective cohort of 2006 individuals with drug-susceptible tuberculosis in India, 18% had unfavorable treatment outcomes (4.7% treatment failure, 2.5% recurrent infection, 4.1% death, 6.8% loss to follow-up) over a median 12-month follow-up period. Age, male sex, low education, nutritional status, and alcohol use were predictors of unfavorable outcomes.

Keywords: epidemiology; prospective cohort; risk factors; treatment outcome; tuberculosis.

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Conflict of interest statement

Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Figures

Figure 1.
Figure 1.
Tuberculosis treatment outcomes of participants with pulmonary tuberculosis by sites enrolled in the Regional Perspective Observational Research for Tuberculosis–India study (2014–2019). Abbreviations: BJGMC, Byramjee Jeejeebhoy Government Medical College; CMC, Christian Medical College; JIPMER, Jawaharlal Institute of Postgraduate Medical Education and Research; MVDRC, Professor M. Viswanathan Diabetes Research Centre (Prof. MVDRC); NIRT, National Institute for Research in Tuberculosis.
See this image and copyright information in PMC

References

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