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Editorial
. 2025 Jun;21(6):1171-1172.
doi: 10.1080/15548627.2024.2377421. Epub 2024 Jul 11.

Pho81 is a novel regulator of pexophagy induced by phosphate starvation

Yuxiang Huang  1 , Daniel J Klionsky  1
Affiliations
Editorial

Pho81 is a novel regulator of pexophagy induced by phosphate starvation

Yuxiang Huang et al. Autophagy. 2025 Jun.

Abstract

In the budding yeast Saccharomyces cerevisiae, macroautophagy/autophagy can be induced by various types of starvation. It is thought that potential autophagic substrates vary to meet specific nutritional demands under different starvation conditions. In a recent study, Gross et al. found that autophagy induced by phosphate starvation includes many selective aspects. For example, this work identified Pho81 as a regulator of pexophagy under conditions of phosphate starvation. Pho81 senses phosphate metabolites and directly interacts with Atg11 to promote Atg1-mediated Atg11 phosphorylation. This finding provides an example of how modulation of the Atg1/ULK kinase complex can convey specific metabolic information to regulate autophagic substrates.Abbreviation: AKC: Atg1/ULK kinase complex.

Keywords: Atg11 phosphorylation; GFP-Atg8 processing assay; SPX domain; autophagy; proteomics.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

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References

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