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Review
. 1985 Mar-Apr;67(3-4):391-2.
doi: 10.1016/s0300-9084(85)80086-9.

Chemical carcinogens and proto-oncogens activation

J Laval, B S Strauss
Review

Chemical carcinogens and proto-oncogens activation

J Laval et al. Biochimie. 1985 Mar-Apr.

Abstract

The induction of proto-oncogens H-ras-1 by nitrosomethylurea (Sukumar et al. (1983), 306, 658-661) is discussed in term of lack of DNA-repair of lesions induced in DNA by this alkylating agent, particularly O6-methylguanine residues and apurinic/apyrimidinic sites.

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