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Review
. 2024 Jun 27:11:1333005.
doi: 10.3389/fcvm.2024.1333005. eCollection 2024.

Gut microbiota: a potential new regulator of hypertension

Yanmin Ge  1 , Jiaxin Wang  2 , Lincong Wu  1 , Junduo Wu  1
Affiliations
Review

Gut microbiota: a potential new regulator of hypertension

Yanmin Ge et al. Front Cardiovasc Med. .

Abstract

Hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases and has become a global public health concern. Although hypertension results from a combination of factors, the specific mechanism is still unclear. However, increasing evidence suggests that gut microbiota is closely associated with the development of hypertension. We provide a summary of the composition and physiological role of gut microbiota. We then delve into the mechanism of gut microbiota and its metabolites involved in the occurrence and development of hypertension. Finally, we review various regimens for better-controlling hypertension from the diet, exercise, drugs, antibiotics, probiotics, and fecal transplantation perspectives.

Keywords: blood pressure; gut microbiota; hypertension; lipopolysaccharide; short-chain fatty acids.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The role of gut microbiota in hypertension.
Figure 2
Figure 2
Selection of treatment plans for gut microbiota in patients with hypertension.
See this image and copyright information in PMC

References

    1. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. (2021) 398(10304):957–80. 10.1016/S0140-6736(21)01330-1 - DOI - PMC - PubMed
    1. Olsen MH, Angell SY, Asma S, Boutouyrie P, Burger D, Chirinos JA, et al. A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the lancet commission on hypertension. Lancet. (2016) 388(10060):2665–712. 10.1016/S0140-6736(16)31134-5 - DOI - PubMed
    1. Dai Y, Shen Z, Khachatryan LG, Vadiyan DE, Karampoor S, Mirzaei R. Unraveling mechanistic insights into the role of microbiome in neurogenic hypertension: a comprehensive review. Pathol Res Pract. (2023) 249:154740. 10.1016/j.prp.2023.154740 - DOI - PubMed
    1. Luqman A, Hassan A, Ullah M, Naseem S, Ullah M, Zhang L, et al. Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder. Front Immunol. (2024) 15:1321395. 10.3389/fimmu.2024.1321395 - DOI - PMC - PubMed
    1. Miao C, Xu X, Huang S, Kong L, He Z, Wang Y, et al. The causality between gut microbiota and hypertension and hypertension-related complications: a bidirectional two-sample mendelian randomization analysis. Hellenic J Cardiol. (2024). 10.1016/j.hjc.2024.02.002 - DOI - PubMed

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