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. 2024 Jun 27:12:1418385.
doi: 10.3389/fpubh.2024.1418385. eCollection 2024.

The association between SII and aging: evidence from NHANES 1999-2018

Nanbu Wang #  1 , Lian Ren #  2 , Ziyuan Li #  3 , Yunhao Hu  3 , Jingpei Zhou  3 , Quan Sun  3 , Bin Pei  4 , Xinyu Li  3 , Wanqing Peng  3 , Jinyan Yu  3 , Renhui Zhao  3 , Ziting Huang  3 , Zhenhu Chen  5 , Guoxin Huang  4
Affiliations

The association between SII and aging: evidence from NHANES 1999-2018

Nanbu Wang et al. Front Public Health. .

Abstract

Background: The study aimed to examine the association between the systemic immune-inflammation index (SII), a contemporary metric of systemic inflammatory response, and biological aging, which are closely interconnected processes.

Methods: This cross-sectional study utilized 10 cycles of data from the NHANES database spanning from 1990 to 2018. The study examined the relationship between the SII index, calculated as P * N/L, where P represents preoperative peripheral platelet count, N represents neutrophil count, and L represents lymphocyte count, and biological aging. Biological aging was assessed through various methods, such as phenotypic age, phenotypic age acceleration (PhenoAgeAccel), biological age, and biological age acceleration (BioAgeAccel). Correlations were analyzed using weighted linear regression and subgroup analysis.

Results: Among the 7,491 participants analyzed, the average age was 45.26 ± 0.34 years, with 52.16% being female. The average phenotypic and biological ages were 40.06 ± 0.36 and 45.89 ± 0.32 years, respectively. Following adjustment for potential confounders, elevated SII scores were linked to increased phenotypic age, biological age, Phenotypic age acceleration, and Biological age acceleration. Positive correlations were observed between health behavior and health factor scores and biological aging, with stronger associations seen for health factors. In health factor-specific analyses, the β coefficient was notably higher for high BMI. The robust positive associations between SII scores and both phenotypic age and biological age in the stratified analyses were consistently observed across all strata.

Conclusion: The evidence from the NHANES data indicate that SII may serve as a valuable marker for assessing different facets of aging and health outcomes, such as mortality and the aging process. Additional research is warranted to comprehensively elucidate the implications of SII in the aging process and its utility as a clinical instrument for evaluating and addressing age-related ailments.

Keywords: NHANES; aging; biological age; phenotypic age; systemic immune-inflammatory index.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the participant selection from NHANES 1999–2018.
See this image and copyright information in PMC

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