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Comment
. 2024 Aug 14;15(8):e0121124.
doi: 10.1128/mbio.01211-24. Epub 2024 Jul 12.

Seeing the unseen: illuminating Toxoplasma gondii's metabolic manipulation

Diego Huet  1   2 , Victoria Jeffers  3
Affiliations
Comment

Seeing the unseen: illuminating Toxoplasma gondii's metabolic manipulation

Diego Huet et al. mBio. .

Abstract

Intracellular infection by a pathogen induces significant rewiring of host cell signaling and biological processes. Understanding how an intracellular pathogen such as Toxoplasma gondii modulates host cell metabolism with single-cell resolution has been challenged by the variability of infection within cultures and difficulties in separating host and parasite metabolic processes. A new study from Gallego-Lopez and colleagues (G. M. Gallego-López, E. C. Guzman, D. E. Desa, L. J. Knoll, M. C. Skala, mBio e00727-24, 2024, https://doi.org/10.1128/mbio.00727-24) applies a quantitative imaging approach to evaluate the host cell metabolism during intracellular infection with Toxoplasma. This study provides important insights into host metabolic responses to Toxoplasma infection and offers a valuable tool to dissect the mechanisms underlying parasite infection and pathophysiology.

Keywords: apicomplexan parasites; confocal microscopy; host-pathogen interactions; metabolism.

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Conflict of interest statement

The authors declare no conflict of interest.

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