Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2024 Sep 13;30(18):3996-4004.
doi: 10.1158/1078-0432.CCR-24-0103.

CSF1R Inhibition in Patients with Advanced Solid Tumors or Tenosynovial Giant Cell Tumor: A Phase I Study of Vimseltinib

Hans Gelderblom  1 , Albiruni A Razak  2 , Matthew H Taylor  3 , Todd M Bauer  4 , Breelyn Wilky  5 , Javier Martin-Broto  6 , Alejandro F Gonzalez  7 , Piotr Rutkowski  8 , Bartlomiej Szostakowski  8 , Thierry Alcindor  9 , Ramy Saleh  9 , Sofia Genta  2 , Silvia Stacchiotti  10 , Michiel van de Sande  1 , Andrew J Wagner  11 , Nicholas Bernthal  12 , Lara E Davis  13 , Jacqueline Vuky  13 , Christopher Tait  14 , Bahar Matin  14 , Supraja Narasimhan  14 , Maitreyi G Sharma  14 , Rodrigo Ruiz-Soto  14 , Matthew L Sherman  14 , William D Tap  15
Affiliations
Clinical Trial

CSF1R Inhibition in Patients with Advanced Solid Tumors or Tenosynovial Giant Cell Tumor: A Phase I Study of Vimseltinib

Hans Gelderblom et al. Clin Cancer Res. .

Abstract

Purpose: Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm caused by dysregulation of the colony-stimulating factor 1 (CSF1) gene and overexpression of the CSF1 ligand. Surgery is the standard of care for most patients, but there are limited treatment options for patients with TGCT not amenable to surgery. This study evaluates vimseltinib, an investigational, oral, switch-control tyrosine kinase inhibitor designed to selectively and potently inhibit the CSF1 receptor.

Patients and methods: This first-in-human, multicenter, open-label phase I/II study of vimseltinib in patients with malignant solid tumors (N = 37) or TGCT not amenable to surgery (N = 32) followed a pharmacologically guided 3 + 3 study design (NCT03069469). The primary objectives were to assess safety and tolerability, determine the recommended phase II dose, and characterize the pharmacokinetics; exploratory objectives included pharmacodynamics and efficacy.

Results: Vimseltinib was well tolerated; the majority of non-laboratory treatment-emergent adverse events were of grade 1/2 severity. There was no evidence of cholestatic hepatotoxicity or drug-induced liver injury. The recommended phase II dose was determined to be 30 mg twice weekly (no loading dose), and vimseltinib plasma exposure increased with the dose. In patients with TGCT, the median treatment duration was 25.1 months (range, 0.7-46.9), and the objective response rate as assessed by independent radiological review using RECIST version 1.1 was 72%.

Conclusions: Vimseltinib demonstrated long-term tolerability, manageable safety, dose-dependent exposure, and robust antitumor activity in patients with TGCT not amenable to surgery.

PubMed Disclaimer

Conflict of interest statement

A.A. Razak reports grants from Deciphera during the conduct of the study, as well as personal fees from Medison outside the submitted work. M.H. Taylor reports other support from Exelixis, Bristol Myers Squibb, OncoSec, Blueprint Medicines, Eisai, Inc., Merck, Immune-Onc, Pfizer, Regeneron, and Sanofi/Genzyme outside the submitted work. T.M. Bauer reports grants from Deciphera during the conduct of the study, as well as personal fees from Pfizer, Bayer, Eli Lilly and Company, Sanofi, and AVEO outside the submitted work. B. Wilky reports personal fees from Deciphera during the conduct of the study, as well as personal fees from SpringWorks and Boehringer Ingelheim outside the submitted work. J. Martín-Broto reports grants from Deciphera during the conduct of the study, as well as grants from Bristol Myers Squibb, Eisai, Immix Biopharma, Pfizer, AROG, Lixte, Karyopharm, Celgene, Blueprint, Adaptimmune, Daichii Sankyo, Rain Therapeutics, Inhibrx, Ayala Pharmaceuticals, Philogen, Cebiotex, PTC Therapeutics, Inc., and SpringWorks Therapeutics outside the submitted work; grants and personal fees from PharmaMar, Eli Lilly and Company, Bayer, GSK, and Amgen; and personal fees from Boehringer Ingelheim, Novartis, Roche, Tecnofarma, and Asofarma. A.F. Gonzalez reports personal fees from Roche, Novartis, AstraZeneca, MSD, Pfizer, Eli Lilly and Company, and Esteve as well as personal fees and nonfinancial support from Gilead and Daiichi Sankyo outside the submitted work. P. Rutkowski reports personal fees from MSD, Bristol Myers Squibb, Pierre Fabre, Deciphera, Genesis Pharma, Novartis, and Medison Pharma outside the submitted work. T. Alcindor reports personal fees from Astellas, Bayer, AstraZeneca, Bristol Myers Squibb, and Merck and other support from Epizyme, SpringWorks Therapeutics, Deciphera, and EMD Serono during the conduct of the study. S. Stacchiotti reports grants from Deciphera during the conduct of the study, as well as grants from Abbisko, Novartis, SpringWorks, Advenchen, Epizyme, Foghorn, Hutchinson, GSK, and Inhibrx; grants and personal fees from Deciphera, Daiichi, Boehringer, and PharmaMar; and personal fees from Bayer, Gentili, Ikena, Ipsen, Servier, Regeneron, PharmaEssentia, Agenus, and Nec Oncology outside the submitted work. M. van de Sande reports other support from Deciphera during the conduct of the study. A.J. Wagner reports grants and personal fees from Deciphera during the conduct of the study, as well as grants and personal fees from Boehringer Ingelheim, Cogent Biosciences, and Daiichi Sankyo and personal fees from Eli Lilly and Company, BioAtla, Servier, Inhibrx, Kymera, and PharmaEssentia outside the submitted work. N. Bernthal reports personal fees from Deciphera and Daiichi Sankyo outside the submitted work. L.E. Davis reports personal fees from SpringWorks, Daiichi Sankyo, Inhibrx, and Regeneron outside the submitted work. J. Vuky reports other support from Deciphera during the conduct of the study, as well as other support from Deciphera, Arvinas, Bristol Myers Squibb, Fortis, Exelixis, Astellas, Eli Lilly and Company, AstraZeneca, Merck, and Pfizer outside the submitted work; J. Vuky also reports current employment with Genentech but not during the conduct of the study. C. Tait reports employment with Deciphera and ownership of stock in Deciphera. B. Matin reports employment with Deciphera Pharmaceuticals, LLC, and holding stock/other ownership interests in Deciphera Pharmaceuticals, LLC. S. Narasimhan reports personal fees and other support from Deciphera Pharmaceuticals and other support from Red Nucleus during the conduct of the study, as well as personal fees and other support from Deciphera Pharmaceuticals outside the submitted work. M.G. Sharma reports personal fees and other support from Deciphera Pharmaceuticals during the conduct of the study. R. Ruiz-Soto reports other support from Deciphera Pharmaceuticals during the conduct of the study and outside the submitted work; R. Ruiz-Soto also reports a patent for Methods of Treating Disorders Using CSF1R Inhibitors issued and pending. M.L. Sherman reports personal fees, nonfinancial support, and other support from Deciphera Pharmaceuticals during the conduct of the study, as well as personal fees, nonfinancial support, and other support from Pieris Pharmaceuticals outside the submitted work. W.D. Tap reports other support from Deciphera during the conduct of the study; personal fees from Avacta, Inhibrx, Aadi, Abbisko, Ikena, Curadev, Servier, Deciphera, Eli Lilly and Company, Foghorn, Pharma Essential, Daiichi, AmMax Bio, Cogent, BioAtla, Boehringer, Ipsen, Bayer, and C4 Therapeutics outside the submitted work; a patent for Enigma CDK4 Inhibition issued; and relationships with Atropos, Certis (founder stock ownership and scientific advisory board), Innova (stock ownership and scientific advisory board), and Osteosarcoma Institute (scientific advisory board). No disclosures were reported by the other authors.

Figures

Figure 1.
Figure 1.
A, Phase I dose escalation design and enrollment. B, Patient enrollment and disposition. One patient with TGCT discontinued treatment but remained on study at the data cutoff. aAfter a 5-day 10 mg once daily loading dose. bAfter a 5-day 20 mg once daily loading dose. cAfter a 5-day 30 mg once daily loading dose. dAfter a 5-day 40 mg once daily loading dose. eAfter a 3-day 50 mg once daily loading dose. fAfter a 3-day 30 mg once daily loading dose. gAfter a 3-day 20 mg once daily loading dose.
Figure 2.
Figure 2.
Pharmacodynamics of vimseltinib in patients with MST or TGCT. A, NCM percentage change from baseline at C2D1. B, NCM percentage change from baseline over time in TGCT cohorts. C, CSF1 fold change in response to vimseltinib at C2D1. D, Plasma CSF1 fold change over time in TGCT cohorts. Cohort 5 received vimseltinib twice weekly, whereas cohorts 8 and 9 received vimseltinib daily. All data are shown as mean ± SD. C, cycle; D, day.
Figure 3.
Figure 3.
Best percentage change from baseline in tumor size of the target lesion, assessed by IRR per RECIST v1.1 and TVS, and time on treatment for patients with TGCT receiving vimseltinib. A, Swimlane plot of duration of treatment and response based on IRR per RECIST v1.1 and best percentage change assessed by IRR using B, RECIST v1.1 and C, TVS. In A, the shaded regions represent the DOR. The dotted lines at 20% in B and 30% in C represent the threshold for PD; the dotted lines at −30% in B and −50% in C represent the threshold for PR. NE, not evaluable.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Stanley ER, Chitu V. CSF-1 receptor signaling in myeloid cells. Cold Spring Harb Perspect Biol 2014;6:a021857. - PMC - PubMed
    1. Cannarile MA, Weisser M, Jacob W, Jegg AM, Ries CH, Ruttinger D. Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy. J Immunother Cancer 2017;5:53. - PMC - PubMed
    1. Casanova-Acebes M, Dalla E, Leader AM, LeBerichel J, Nikolic J, Morales BM, et al. . Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature 2021;595:578–84. - PMC - PubMed
    1. Yin S, Huang J, Li Z, Zhang J, Luo J, Lu C, et al. . The prognostic and clinicopathological significance of tumor-associated macrophages in patients with gastric cancer: a meta-analysis. PLoS One 2017;12:e0170042. - PMC - PubMed
    1. Zhao X, Qu J, Sun Y, Wang J, Liu X, Wang F, et al. . Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature. Oncotarget 2017;8:30576–86. - PMC - PubMed

Publication types

MeSH terms

Substances