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Review
. 2024 Sep;37(5):1290-1305.
doi: 10.1007/s13577-024-01102-w. Epub 2024 Jul 12.

Recent advances in nanomaterials for the treatment of femoral head necrosis

Yalin Yuan  1   2 , Mi Zou  1   2 , Shuqin Wu  1   2 , Congcong Liu  1   2 , Liang Hao  3
Affiliations
Review

Recent advances in nanomaterials for the treatment of femoral head necrosis

Yalin Yuan et al. Hum Cell. 2024 Sep.

Abstract

Osteonecrosis of the femoral head (ONFH) is a condition that causes considerable pain and discomfort for patients, and its pathogenic mechanisms are not yet fully understood. While there have been many studies that suggest multiple factors may contribute to its development, current treatments involve both surgical and nonsurgical options. However, there is still much room for improvement in these treatment methods, particularly when it comes to preventing postoperative complications and optimizing surgical procedures. Nanomaterials, as a type of small molecule material, have shown great promise in treating bone tissue diseases, including ONFH. In fact, several nanocomposite materials have demonstrated specific effects in preventing ONFH, promoting bone tissue repair and growth, and optimizing surgical treatment. This article provides a comprehensive overview of current treatments for ONFH, including their advantages and limitations, and reviews the latest advances in nanomaterials for treating this condition. Additionally, this article explores the therapeutic mechanisms involved in using nanomaterials to treat ONFH and to identify new methods and ideas for improving outcomes for patients.

Keywords: Nanomaterial; Osteonecrosis of the femoral head; Pathogenic mechanisms; Prevention; Treatment.

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