Review

. 2024;14(6):1277-1282.

doi: 10.3233/JPD-240088.

Unmet Need in Early-Onset Parkinson's Disease: Deep Brain Stimulation and Pregnancy

Katarzyna Smilowska^{1

2}, Raja Mehanna³, Jori E Fleisher⁴, Roy N Alcalay^{5

6}, Kishore Raj Kumar^{7

8}, Connie Marras⁹, Annelien M Oosterbaan¹⁰, Bart Post¹⁰, Owen A Ross¹¹, Maria Elisa Pimentel Piemonte¹², Valerie Fraix¹³, Elena Moro¹³, Eng King Tan¹⁴, Rodolfo Savica¹⁵; EOPD Task Force

Affiliations

¹ Department of Neurology, 5th Regional Hospital, Sosnowiec, Poland.
² Silesian Center of Neurology, Katowice, Poland.
³ University of Texas Health Science Center at Houston, Houston, TX, USA.
⁴ Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
⁵ Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
⁶ Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
⁷ Molecular Medicine Laboratory and Department of Neurology, Concord Repatriation General Hospital, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
⁸ Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
⁹ The Edmond J Safra Program in Parkinson's Disease, University Health Network, University of Toronto, Toronto, Canada.
¹⁰ Department of Neurology and Expertise Center for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
¹¹ Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
¹² Physical Therapy, Speech Therapy, and Occupational Therapy Department, University of São Paulo, São Paulo, Brazil.
¹³ Grenoble Alpes University, Division of Neurology, CHU of Grenoble, Grenoble Institute of Neurosciences, Grenoble, France.
¹⁴ National Neuroscience Institute, Singapore, Singapore.
¹⁵ Department of Neurology and Health Science Research, Mayo Clinic, Rochester, MN, USA.

PMID: 38995803
PMCID: PMC11380313
DOI: 10.3233/JPD-240088

Review

Unmet Need in Early-Onset Parkinson's Disease: Deep Brain Stimulation and Pregnancy

Katarzyna Smilowska et al. J Parkinsons Dis. 2024.

. 2024;14(6):1277-1282.

doi: 10.3233/JPD-240088.

Authors

Affiliations

¹ Department of Neurology, 5th Regional Hospital, Sosnowiec, Poland.
² Silesian Center of Neurology, Katowice, Poland.
³ University of Texas Health Science Center at Houston, Houston, TX, USA.
⁴ Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
⁵ Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
⁶ Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
⁷ Molecular Medicine Laboratory and Department of Neurology, Concord Repatriation General Hospital, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
⁸ Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
⁹ The Edmond J Safra Program in Parkinson's Disease, University Health Network, University of Toronto, Toronto, Canada.
¹⁰ Department of Neurology and Expertise Center for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
¹¹ Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
¹² Physical Therapy, Speech Therapy, and Occupational Therapy Department, University of São Paulo, São Paulo, Brazil.
¹³ Grenoble Alpes University, Division of Neurology, CHU of Grenoble, Grenoble Institute of Neurosciences, Grenoble, France.
¹⁴ National Neuroscience Institute, Singapore, Singapore.
¹⁵ Department of Neurology and Health Science Research, Mayo Clinic, Rochester, MN, USA.

PMID: 38995803
PMCID: PMC11380313
DOI: 10.3233/JPD-240088

Abstract

Pregnancy in women with early-onset Parkinson's disease (PD) is likely to have a higher frequency given the trend toward increasing maternal age, thus resulting in a greater overlap time between childbearing age and PD risk. Deep brain stimulation (DBS) therapy is nowadays offered to PD patients at earlier stage of the disease, when women can still be pre-menopausal. However, few data are available about DBS safety during pregnancy. From a review of the available literature, only one article was published on this topic so far. Therefore, we have developed a clinical consensus on the safety of DBS during pregnancy in PD patients.

Keywords: Parkinson’s disease; deep brain stimulation; pregnancy.

PubMed Disclaimer

Conflict of interest statement

R. Savica, R.N. Alcalay, and E.-K. Tan are Editorial Board members of this journal, but were not involved in the peer-review process of this article nor had access to any information regarding its peer review.

R. Mehanna is on the speaker bureau for TEVA and Kyowa Kirin. He has received research grants from, Global Kinetic Corporation, Northera, Neurocrine, and Cerevel.

J.E. Fleisher reports royalties from UpToDate, Inc; honoraria from Parkinson’s Foundation & Davis Phinney Foundation, and research support from NIH, Parkinson’s Foundation, and CurePSP.

R.N. Alcalay reports consultation fees from Avrobio, Caraway, GSK, Merck, Ono Therapeutics, and Sanofi; and research support from NIH, DoD, the Parkinson’s Foundation, and The Michael. J. Fox Foundation. RN institution (TLVMC) is supported by Biogen.

K.R. Kumar received honoraria from Seqirus, Abbvie, Research Review Australia, The International Parkinson and Movement Disorder Society (MDS), and grant funding from the Paul Ainsworth Family Foundation and the Medical Research Future Fund.

C. Marras reports research support from the Michael J Fox Foundation, the Parkinson’s Foundation and the Canadian Institutes of Health Research.

O.A. Ross reports research support from NIH, DoD, the Parkinson’s, The Michael. J. Fox Foundation and American Brain Foundation.

V. Fraix reports consultancies for Abbott, Medtronic, and Kyowa and major grants from Medtronic and Ipsen. She received payment for lectures from Abbott and Medtronic.

E. Moro reports consultancies for Abbott, Medtronic, and Kyowa and major grants from Medtronic and Ipsen. She received payment for lectures from Abbott and Medtronic.

E.-K. Tan received honoraria for editorial duties for Clinical Parkinsonism Related Disorders and grant support from the National Medical Research Council, Singapore.

R. Savica received research support from the National Institute on Aging, the National Institute of Neurological Disorders and Stroke, and the Mayo Clinic Small Grants Program

National Center for Advancing Translational Sciences (NCATS) and an unrestricted research grant from Acadia Pharmaceuticals, Inc.

All other authors have no conflict of interest to report.

References

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Unmet Need in Early-Onset Parkinson's Disease: Deep Brain Stimulation and Pregnancy

Affiliations

Unmet Need in Early-Onset Parkinson's Disease: Deep Brain Stimulation and Pregnancy

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical