Review
doi: 10.1007/BF03189702.
Pharmacokinetics and metabolism of vincamine and related compounds
- PMID: 3899662
- DOI: 10.1007/BF03189702
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Review
Pharmacokinetics and metabolism of vincamine and related compounds
Eur J Drug Metab Pharmacokinet.
1985 Apr-Jun.
Abstract
The pharmacokinetics and metabolism of vincamine, vinpocetine, methylene-methoxy-apovincaminic acid ester and eburnamine have been reviewed. The main route of elimination for vincamine, vinpocetine and methylene-methoxy-apovincaminic acid ester is ester cleavage and conjugation in the case of eburnamine. Vincamine and its derivatives show significant differences in metabolic pathway and their elimination is rapid in the species studied. Emphasis has been placed on the analytical methods used for monitoring these drugs in biological systems.
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