Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2024 Jul 12;28(1):237.
doi: 10.1186/s13054-024-04989-x.

Resilience after severe critical illness: a prospective, multicentre, observational study (RESIREA)

Alice Mathieu  1 , Jean Reignier  2   3   4 , Amélie Le Gouge  5   6 , Gaetan Plantefeve  7 , Jean-Paul Mira  8 , Laurent Argaud  9 , Pierre Asfar  10 , Julio Badie  11 , Nicolae-Vlad Botoc  12 , Hoang-Nam Bui  13 , Delphine Chatellier  14 , Louis Chauvelot  15 , Christophe Cracco  16 , Michael Darmon  17 , Agathe Delbove  18 , Jérôme Devaquet  19 , Louis-Marie Dumont  20 , Olivier Gontier  21 , Samuel Groyer  22 , Yannick Hourmant  23 , Samir Jaber  24   25 , Fabien Lambiotte  26 , Benjamin Madeux  27 , Julien Maizel  28 , Olivier Martinet  29 , Virginie Maxime  30   31 , Emmanuelle Mercier  32 , Mai-Anh Nay  33 , Saad Nseir  34   35 , Gael Piton  36   37 , Jean-Pierre Quenot  38   39   40 , Anne Renault  41 , Jean-Philippe Rigaud  42 , Francis Schneider  43 , Michel Sirodot  44 , Bertrand Souweine  45 , Fabienne Tamion  46 , Didier Thévenin  47 , Nathalie Thieulot-Rolin  48 , Francois Tinturier  49 , Patrice Tirot  50 , Isabelle Vinatier  51 , Christophe Vinsonneau  52 , Jean-Baptiste Lascarrou  53   54 , Alexandra Laurent  55   56   57 ; NUTRIREA-3 Trial Investigators; Clinical Research In Intensive Care and Sepsis (CRICS-TRIGGERSEP) Group
Affiliations
Observational Study

Resilience after severe critical illness: a prospective, multicentre, observational study (RESIREA)

Alice Mathieu et al. Crit Care. .

Abstract

Background: Critical-illness survivors may experience post-traumatic stress disorder (PTSD) and quality-of-life impairments. Resilience may protect against psychological trauma but has not been adequately studied after critical illness. We assessed resilience and its associations with PTSD and quality of life, and also identified factors associated with greater resilience.

Methods: This prospective, multicentre, study in patients recruited at 41 French ICUs was done in parallel with the NUTRIREA-3 trial in patients given mechanical ventilation and vasoactive amines for shock. Three months to one year after intensive-care-unit admission, survivors completed the Connor-Davidson Resilience Scale (CD-RISC-25), Impact of Event-Revised scale for PTSD symptoms (IES-R), SF-36 quality-of-life scale, Multidimensional Scale of Perceived Social Support (MSPSS), and Brief Illness Perception Questionnaire (B-IPQ).

Results: Of the 382 included patients, 203 (53.1%) had normal or high resilience (CD-RISC-25 ≥ 68). Of these resilient patients, 26 (12.8%) had moderate to severe PTSD symptoms (IES-R ≥ 24) vs. 45 (25.4%) patients with low resilience (p = 0.002). Resilient patients had higher SF-36 scores. Factors independently associated with higher CD-RISC-25 scores were higher MSPSS score indicating stronger social support (OR, 1.027; 95%CI 1.008-1.047; p = 0.005) and lower B-IPQ scores indicating a more threatening perception of the illness (OR, 0.973; 95%CI 0.950-0.996; p = 0.02).

Conclusions: Resilient patients had a lower prevalence of PTSD symptoms and higher quality of life scores, compared to patients with low resilience. Higher scores for social support and illness perception were independently associated with greater resilience. Thus, our findings suggest that interventions to strengthen social support and improve illness perception may help to improve resilience. Such interventions should be evaluated in trials with PTSD mitigation and quality-of-life improvement as the target outcomes.

Keywords: Critical illness; Illness perception; Post-traumatic stress disorder; Quality of life; Resilience; Social support.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests related to this article.

Figures

Fig. 1
Fig. 1
Flow chart. ICU: intensive care unit
See this image and copyright information in PMC

References

    1. Parker AM, Sricharoenchai T, Raparla S, Schneck KW, Bienvenu OJ, Needham DM. Posttraumatic stress disorder in critical illness survivors: a metaanalysis*. Crit Care Med. 2015;43(5):1121–1129. doi: 10.1097/CCM.0000000000000882. - DOI - PubMed
    1. Boer KR, Mahler CW, Unlu C, Lamme B, Vroom MB, Sprangers MA, et al. Long-term prevalence of post-traumatic stress disorder symptoms in patients after secondary peritonitis. Crit Care. 2007;11(1):R30. doi: 10.1186/cc5710. - DOI - PMC - PubMed
    1. Cuthbertson BH, Hull A, Strachan M, Scott J. Post-traumatic stress disorder after critical illness requiring general intensive care. Intensiv Care Med. 2004;30(3):450–455. doi: 10.1007/s00134-003-2004-8. - DOI - PubMed
    1. Svenningsen H, Langhorn L, Ågård AS, Dreyer P. Post-ICU symptoms, consequences, and follow-up: an integrative review: review post-ICU. Nurs Crit Care. 2017;22(4):212–220. doi: 10.1111/nicc.12165. - DOI - PubMed
    1. Yehuda R. 011002 Post-Traumatic Stress Disorder. N Engl J Med. - PubMed

Publication types