Simplified preanalytical laboratory procedures for therapeutic drug monitoring (TDM) in patients treated with high-dose methotrexate (HD-MTX) and glucarpidase

Franz L Knörnschild¹, Sven Liebig², Peggy Kießling³, Monika Prpic¹, Tehyung Kim², Ulrich Keller^{2

4

5}, Kai Kappert^{1

3}, Stefan Schwartz^{2

4}, Amir Jahic^{1

3}

Affiliations

¹ Institute of Diagnostic Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité - Universitätsmedizin Berlin, Berlin, Germany.
² Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
³ Labor Berlin - Charité Vivantes GmbH, Berlin, Germany.
⁴ German Cancer Consortium (DKTK), Partner Site Berlin, A Partnership Between DKFZ and Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁵ Max-Delbrück-Center, Berlin, Germany.

Franz L Knörnschild et al. Clin Chem Lab Med. 2024.

. 2024 Jul 15;63(1):e11-e15.

doi: 10.1515/cclm-2024-0523. Print 2025 Jan 29.

Franz L Knörnschild¹, Sven Liebig², Peggy Kießling³, Monika Prpic¹, Tehyung Kim², Ulrich Keller^{2

4

5}, Kai Kappert^{1

3}, Stefan Schwartz^{2

4}, Amir Jahic^{1

3}

¹ Institute of Diagnostic Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité - Universitätsmedizin Berlin, Berlin, Germany.
² Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
³ Labor Berlin - Charité Vivantes GmbH, Berlin, Germany.
⁴ German Cancer Consortium (DKTK), Partner Site Berlin, A Partnership Between DKFZ and Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁵ Max-Delbrück-Center, Berlin, Germany.

No abstract available

Keywords: drug monitoring; glucarpidase; kidney failure; methotrexate.

References

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1. Garneau, AP, Riopel, J, Isenring, P. Acute methotrexate-induced crystal nephropathy. N Engl J Med 2015;373:2691–3. https://doi.org/10.1056/nejmc1507547 . - DOI
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1. Schwartz, S, Borner, K, Muller, K, Martus, P, Fischer, L, Korfel, A, et al.. Glucarpidase (carboxypeptidase g2) intervention in adult and elderly cancer patients with renal dysfunction and delayed methotrexate elimination after high-dose methotrexate therapy. Oncologist 2007;12:1299–308. https://doi.org/10.1634/theoncologist.12-11-1299 . - DOI
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