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. 2024 Jul 6;17(13):3352.
doi: 10.3390/ma17133352.

Engineered Mesoporous Silica-Based Nanoparticles: Characterization of Surface Properties

Antonio Grisolia  1 , Marzia De Santo  2 , Manuela Curcio  2 , Palmira Alessia Cavallaro  2 , Catia Morelli  2 , Antonella Leggio  2 , Luigi Pasqua  1
Affiliations

Engineered Mesoporous Silica-Based Nanoparticles: Characterization of Surface Properties

Antonio Grisolia et al. Materials (Basel). .

Abstract

Mesoporous silica-based nanomaterials have emerged as multifunctional platforms with applications spanning catalysis, medicine, and nanotechnology. Since their synthesis in the early 1990s, these materials have attracted considerable interest due to their unique properties, including high surface area, tunable pore size, and customizable surface chemistry. This article explores the surface properties of a series of MSU-type mesoporous silica nanoparticles, elucidating the impact of different functionalization strategies on surface characteristics. Through an extensive characterization utilizing various techniques, such as FTIR, Z-potential, and nitrogen adsorption porosimetry, insights into the surface modifications of mesoporous silica nanoparticles are provided, contributing to a deeper understanding of their nanostructure and related interactions, and paving the way to possible unexpected actionability and potential applications.

Keywords: external functionalization; grafting; mesoporous silica nanoparticles; surface properties; zeta-potential.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Scheme 1
Scheme 1
Workflow diagram of MSN grafting protocols.
Figure 1
Figure 1
SEM micrograph image of MSNAS.
Figure 2
Figure 2
TEM micrograph image of MSNAS (scale bar 100 nm).
Figure 3
Figure 3
XRD pattern of synthesized MSU-x: MSNAS.
Figure 4
Figure 4
FTIR pattern of synthesized MSU-x: MSNAS.
Figure 5
Figure 5
TGA-DSC pattern of synthesized MSU-x: MSNAS.
Figure 6
Figure 6
DSC: onset, end, peak, and enthalpy values.
Figure 7
Figure 7
Zeta-potential pattern of synthesized MSU-x: MSNAS.
Scheme 2
Scheme 2
Graphical representation of grafting of MSNAS.
Figure 8
Figure 8
Z-potential graphs comparison of sample (a) MSN-Ap vs. FOL-MSN and (b) FOL-MSN vs. FOL-MSN-EXT.
Figure 9
Figure 9
Z-potential graphs comparison of sample (a) FOL-MSN-EXT vs. FOL-MSN-DIOL; (b) FOL-MSN-EXT vs. FOL-MSN-NH2; (c) FOL-MSN-NH2 vs. FOL-MSN-COOH; (d) FOL-MSN-COOH vs. FOL-MSN-HYD.
Figure 10
Figure 10
FTIR spectra overlap of MSN-AP, FOL-MSN, and FOL-MSN-EXT samples.
Figure 11
Figure 11
FTIR spectra overlap of MSN-FOL-EXT and MSN-FOL-GLY and MSN-FOL-DIOL samples.
Figure 12
Figure 12
FTIR spectra overlap of FOL-MSN-EXT, FOL-MSN-NH2, FOL-MSN-COOH, and FOL-MSN-HYD samples.
Figure 13
Figure 13
Adsorption isotherm overlap of (a) MSNAS, MSN-AP, FOL-MSN and FOL-MSN-EXT samples; (b) FOL-MSN-NH2, FOL-MSN-EXT, FOL-MSN-COOH, and FOL-MSN-HYD samples; (c) FOL-MSN-EXT vs. FOL-MSN-DIOL samples.
Scheme 3
Scheme 3
Flow chart of results and scientific contribution.
See this image and copyright information in PMC

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