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. 2024 Jun 26;13(13):2022.
doi: 10.3390/foods13132022.

Structural and Release Properties of Combined Curcumin Controlled-Release Tablets Formulated with Chitosan/Sodium Alginate/HPMC

Jing-Ting Lin  1 , Yi-Chan Chiang  1   2 , Po-Hsien Li  2 , Po-Yuan Chiang  1
Affiliations

Structural and Release Properties of Combined Curcumin Controlled-Release Tablets Formulated with Chitosan/Sodium Alginate/HPMC

Jing-Ting Lin et al. Foods. .

Abstract

Controlled-release tablets offer several benefits, such as controlled release, odor masking, ease of use, stability, extended shelf life, and reduced production costs. This study developed combined curcumin controlled-release tablets (CCCTs) to increase the bioavailability of curcumin with hydroxypropyl methylcellulose (HPMC), chitosan, and sodium alginate. The hardness of the CCCTs was 5.63-1.98 kgf, friability was 0.00-1.22%, and disintegration time was 0.00-401.25 min. Differential scanning calorimetry and Fourier-transform infrared spectroscopy indicated a high compatibility between the excipients and curcumin. CCCTs with chitosan formed a gel structure, impeded disintegration, and reduced the release rate to 72.5% in simulated gastric fluid. In simulated intestinal fluid, CCCT with the HPMC-sodium alginate group formed a polyelectrolyte membrane hydrogel to prolong release from 6 to 12 h. This study developed various CCCT formulations that can be delivered through the gastric or intestinal tracts, using chitosan and HPMC-sodium alginate as excipients, respectively. CCCT can be used as a reference strategy for controlled-release curcumin delivery in the functional and healthcare supplement development.

Keywords: combined controlled-release tablet; curcumin; simulated gastrointestinal tract.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The appearance of combined curcumin controlled-release tablets (A–G: different tablet formulae).
Figure 2
Figure 2
Thermograms and FTIR spectra of ingredients, particle blend, and combined curcumin controlled-release tablets. (A) Differential scanning calorimetry; (B) Fourier-transform infrared spectroscopy. HPMC: hydroxypropyl methylcellulose, MCC: microcrystalline cellulose, and MgSt: magnesium stearate.
Figure 3
Figure 3
Simulated in vitro simulated gastrointestinal digestion of combined curcumin controlled-release tablets. (A) FTIR spectra; (B) release rate of curcumin; (C) microstructure.
See this image and copyright information in PMC

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