Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jun 22;13(13):3650.
doi: 10.3390/jcm13133650.

Effects of Chemotherapy on Aneuploidy Rates in Sperm from Male Patients with Testicular Cancer or Hodgkin's Lymphoma-A Systematic Review

Jasmin Nissi  1   2 , Laila Kalam  1   2 , Laura Catalini  1   2 , Jens Fedder  1   2
Affiliations
Review

Effects of Chemotherapy on Aneuploidy Rates in Sperm from Male Patients with Testicular Cancer or Hodgkin's Lymphoma-A Systematic Review

Jasmin Nissi et al. J Clin Med. .

Abstract

Background: Testicular cancer and Hodgkin's lymphoma are prevalent malignancies among young males aged 20 to 39. The incidence of testicular cancer and lymphoma has risen in recent years, with orchiectomy often followed by adjuvant chemotherapy as the primary treatment for testicular cancer and chemotherapy for lymphoma. Chemotherapy has been associated with an increased risk of aneuploidy and reduced fertility.

Method: This systematic review included seven studies, both case-control and longitudinal prospective designs, from the PubMed, Embase, and Cochrane Library databases. The screening process was conducted using the online tool covidence.org.

Results: The study outcomes indicate varied impacts of chemotherapy on aneuploidy rates. An increase in the aneuploidy rates, notably for the sex chromosomes, immediately post-treatment was a common trend, followed by a decline in pretreatment values.

Conclusion: This systematic review presents the effects of chemotherapy on the aneuploidy rates of testicular cancer and Hodgkin's lymphoma patients, with a decrease post-treatment. The findings underscore the need for larger, well-designed studies with a longer study period.

Keywords: aneuploidy; cancer; chemotherapy; male; spermatogenesis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flowchart diagram. * The initial search in the databases yielded a total of 1114 studies, with an additional 2 papers obtained through expert knowledge.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Cancer Council . In: Understanding Testicular Cancer. A Guide for People with Cancer, Their Families, and Friends. Sheard R., editor. Cancer Council Australia; Sydney, NSW, Australia: 2023. pp. 8–34.
    1. Amini R.M., Enblad G. Relationship between Hodgkin’s and non-Hodgkin’s lymphomas. Med. Oncol. 2003;20:211–220. doi: 10.1385/MO:20:3:211. - DOI - PubMed
    1. Park J.S., Kim J., Elghiaty A., Ham W.S. Recent global trends in testicular cancer incidence and mortality. Medicine. 2018;37:e12390. doi: 10.1097/MD.0000000000012390. - DOI - PMC - PubMed
    1. Shaw J. Diagnosis and treatment of testicular cancer. Am. Fam. Physician. 2008;77:469–474. - PubMed
    1. Green D.M., Liu W., Kutteh W.H., Ke R.W., Shelton K.C., Sklar C.A., Chemaitilly W., Pui C.H., Klosky J.L., Spunt S.L., et al. Cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cancer: A report from the St Jude Lifetime Cohort Study. Lancet Oncol. 2014;15:1215–1223. doi: 10.1016/S1470-2045(14)70408-5. - DOI - PMC - PubMed

LinkOut - more resources