Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep;17(9):1101-1112.
doi: 10.1016/j.jcmg.2024.05.016. Epub 2024 Jul 10.

Rationale and Design of SCOT-HEART 2 Trial: CT Angiography for the Prevention of Myocardial Infarction

Michael McDermott  1 , Mohammed N Meah  2 , Phyo Khaing  3 , Kang-Ling Wang  3 , Jennifer Ramsay  4 , Gillian Scott  5 , Hannah Rickman  5 , Tom Burt  3 , Ian McGowan  3 , Timothy Fairbairn  6 , Marise Bucukoglu  5 , Russell Bull  7 , Adam Timmis  8 , Edwin J R van Beek  9 , Giles Roditi  10 , Philip D Adamson  11 , Steff Lewis  5 , John Norrie  5 , Brian McKinstry  5 , Bruce Guthrie  12 , Lewis Ritchie  13 , Nicholas L Mills  14 , Marc R Dweck  3 , Michelle C Williams  3 , David E Newby  15
Affiliations
Free article

Rationale and Design of SCOT-HEART 2 Trial: CT Angiography for the Prevention of Myocardial Infarction

Michael McDermott et al. JACC Cardiovasc Imaging. 2024 Sep.
Free article

Abstract

Coronary artery disease continues to be the leading cause of death globally. Identifying patients who are at risk of coronary artery disease remains a public health priority. At present, the focus of cardiovascular disease prevention relies heavily on probabilistic risk scoring despite no randomized controlled trials demonstrating their efficacy. The concept of using imaging to guide preventative therapy is not new, but has previously focused on indirect measures such as carotid intima-media thickening or coronary artery calcification. In recent trials, patients found to have coronary artery disease on computed tomography (CT) coronary angiography were more likely to be started on preventative therapy and had lower rates of cardiac events. This led to the design of the SCOT-HEART 2 (Scottish Computed Tomography of the Heart 2) trial, which aims to determine whether screening with the use of CT coronary angiography is more clinically effective than cardiovascular risk scoring to guide the use of primary preventative therapies and reduce the risk of myocardial infarction.

Keywords: CT coronary angiography; risk-scoring.

PubMed Disclaimer

Conflict of interest statement

Funding Support and Author Disclosures Dr McDermott is supported by a British Heart Foundation Clinical Research Training Fellowship (FS/CRTF/23/24491). Drs Mills and Newby are supported by a Chair Award, Programme Grant, and Research Excellence Award (CH/F/21/90010, CH/09/002/26360, RG/20/10/34966, RG/F/22/110093, RE/24/130012) from the British Heart Foundation. The SCOT-HEART 2 trial is funded by the British Heart Foundation (CS/18/4/34074). Dr Williams is supported by the British Heart Foundation (FS/ICRF/20/26002); and has given talks for Canon Medical Systems, Siemens Healthineers, and Novartis. Dr Mills has received research grants, honoraria, or consultancy fees from Abbott Diagnostics, Roche Diagnostics, Siemens Healthineers, LumiraDx, and Pyros Laboratories. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Publication types

LinkOut - more resources