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Review
. 2024 Sep:201:104444.
doi: 10.1016/j.critrevonc.2024.104444. Epub 2024 Jul 13.

Integrating nutrition, physical exercise, psychosocial support and antiemetic drugs into CINV management: The road to success

Lorenzo Belluomini  1 , Alice Avancini  2 , Marco Sposito  3 , Letizia Pontolillo  4 , Daniela Tregnago  5 , Ilaria Trestini  6 , Jessica Insolda  7 , Luisa Carbognin  8 , Michele Milella  9 , Emilio Bria  10 , Sara Pilotto  11
Affiliations
Free article
Review

Integrating nutrition, physical exercise, psychosocial support and antiemetic drugs into CINV management: The road to success

Lorenzo Belluomini et al. Crit Rev Oncol Hematol. 2024 Sep.
Free article

Abstract

Over the years, advancements in antiemetic drugs have improved chemotherapy-induced nausea and vomiting (CINV) control. However, despite the antiemetics therapies, in a relevant number of adult patients (∼30 %), CINV is still persistent, leading to several complications, such as electrolyte imbalances, anorexia, and treatment discontinuation. Supportive care interventions have gained credibility in cancer care, helping to improve patients' psycho-physical condition, quality of life, and managing symptoms, including CINV. Physical exercise and tailored nutritional counseling have demonstrated benefits in reducing the severity of nausea and vomiting. Psychological intervention has been postulated as a key approach in controlling anticipatory nausea/vomiting, as well as acupuncture/acupressure has been shown to decrease nausea and vomiting after chemotherapy treatments. In the current review, we aim to provide a clinical update on current prophylactic and delayed antiemetic guidelines for CINV and an overview of the non-pharmacological interventions tested for alleviating CINV in patients with cancer.

Keywords: CINV; Pharmacological approach; Quality of life; Supportive care.

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Conflict of interest statement

Declaration of Competing Interest LB received speakers’ fees from AstraZeneca, Merck Sharp & Dohme, and Roche, outside the submitted manuscript; travel fees from Takeda. SP received honoraria or speakers’ fees from AstraZeneca, Eli Lilly, Bristol-Myers Squibb, Merck, Takeda, Amgen, Novartis, and Roche, outside the submitted manuscript. E.B. has received grants or contracts from Astra-Zeneca, Roche and honoraria for lectures from Merck-Sharp & Dome, Astra-Zeneca, Pfizer, Eli-Lilly, Bristol-Myers Squibb, Novartis, Takeda and Roche; E.B. has been member of Data Safety Monitoring Board or Advisory Board of Merck-Sharp & Dome, Pfizer, Novartis, Bristol-Myers Squibb, Astra-Zeneca, and Roche. The remaining authors declare no conflict of interest.