Prevotella Is Associated With Sex-Based Differences in Irritable Bowel Syndrome

Tien S Dong¹, Kirstin Peters², Arpana Gupta¹, Jonathan P Jacobs¹; UCLA SCORE Group in IBS and Sex Differences; Lin Chang⁴

Collaborators, Affiliations

Collaborators

UCLA SCORE Group in IBS and Sex Differences:
Swapna Mahurkar-Joshi³, Cathy Liu³, Simer Shera², Jennifer S Labus³, Andrea Shin³, Simer Shera², Emeran A Mayer³

Affiliations

¹ Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California; University of California, Los Angeles Goodman-Luskin Microbiome Center, Los Angeles, California; Department of Medicine, University of California, Los Angeles, Los Angeles, California.
² Department of Medicine, University of California, Los Angeles, Los Angeles, California.
³ Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California; University of California, Los Angeles, Goodman-Luskin Microbiome Center, Los Angeles, California; Department of Medicine, University of California, Los Angeles, Los Angeles, California.
⁴ Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California; University of California, Los Angeles Goodman-Luskin Microbiome Center, Los Angeles, California; Department of Medicine, University of California, Los Angeles, Los Angeles, California. Electronic address: linchang@mednet.ucla.edu.

PMID: 39004155
PMCID: PMC11845270
DOI: 10.1053/j.gastro.2024.07.006

Prevotella Is Associated With Sex-Based Differences in Irritable Bowel Syndrome

Tien S Dong et al. Gastroenterology. 2024 Nov.

. 2024 Nov;167(6):1221-1224.e8.

doi: 10.1053/j.gastro.2024.07.006. Epub 2024 Jul 14.

Authors

Tien S Dong¹, Kirstin Peters², Arpana Gupta¹, Jonathan P Jacobs¹; UCLA SCORE Group in IBS and Sex Differences; Lin Chang⁴

Collaborators

UCLA SCORE Group in IBS and Sex Differences:
Swapna Mahurkar-Joshi³, Cathy Liu³, Simer Shera², Jennifer S Labus³, Andrea Shin³, Simer Shera², Emeran A Mayer³

Affiliations

¹ Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California; University of California, Los Angeles Goodman-Luskin Microbiome Center, Los Angeles, California; Department of Medicine, University of California, Los Angeles, Los Angeles, California.
² Department of Medicine, University of California, Los Angeles, Los Angeles, California.
³ Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California; University of California, Los Angeles, Goodman-Luskin Microbiome Center, Los Angeles, California; Department of Medicine, University of California, Los Angeles, Los Angeles, California.
⁴ Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California; University of California, Los Angeles Goodman-Luskin Microbiome Center, Los Angeles, California; Department of Medicine, University of California, Los Angeles, Los Angeles, California. Electronic address: linchang@mednet.ucla.edu.

PMID: 39004155
PMCID: PMC11845270
DOI: 10.1053/j.gastro.2024.07.006

No abstract available

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Conflict of interest statement

Conflicts of interest

The authors disclose no conflicts.

Figures

**Figure 1.**
Sex-based differences exist in the microbiome of IBS patients, and *Prevotella* is the main driver of those differences. The β diversity of the gut microbiome as depicted by principal coordinate analysis of (A) all participants, including healthy control participants and IBS patients; (B) healthy control participants only; and (C) IBS patients only. Analysis was adjusted for diet, age, body mass index (BMI), race/ethnicity, and bowel subtype if applicable. The a diversity of the gut microbiome as depicted by the Shannon index (a measure of evenness) of (D) IBS patients as compared to control participants, (E) IBS patients across BH subtypes, and (F) IBS patients by IBS-SSS category. (G) Differential abundance testing of bacterial genera by sex adjusted for age, BMI, BH, race/ethnicity, diet, and multiple hypothesis testing. Those genera listed are those with a Q value of < 0.05. Box plots of *Prevotella* relative abundance in (H) male patients with IBS and (I) female patients with IBS categorized by IBS-SSS category. *P < .05. F, female; M, male; PC, principal component.

See this image and copyright information in PMC

References

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Prevotella Is Associated With Sex-Based Differences in Irritable Bowel Syndrome

Collaborators

Affiliations

Prevotella Is Associated With Sex-Based Differences in Irritable Bowel Syndrome

Authors

Collaborators

Affiliations

Conflict of interest statement

Figures

References

Grants and funding

LinkOut - more resources

Full Text Sources