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. 2024 Nov 14;42(25):126136.
doi: 10.1016/j.vaccine.2024.07.037. Epub 2024 Jul 14.

A getah virus-like-particle vaccine provides complete protection from viremia and arthritis in wild-type mice

Qiuhong Miao  1 , Wilson Nguyen  2 , Jie Zhu  3 , Guangqing Liu  4 , Monique M van Oers  5 , Bing Tang  6 , Kexin Yan  7 , Thibaut Larcher  8 , Andreas Suhrbier  9 , Gorben P Pijlman  10
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Free article

A getah virus-like-particle vaccine provides complete protection from viremia and arthritis in wild-type mice

Qiuhong Miao et al. Vaccine. .
Free article

Abstract

Getah virus (GETV) is an emerging mosquito-borne virus with economic impact on the livestock industry in East Asia. In this study, we successfully produced GETV virus-like particles (VLPs) in insect cells using the baculovirus expression vector system. We show that the GETV envelope glycoproteins were successfully expressed at the surface of the insect cell and were glycosylated. VLPs were isolated from the culture fluid as enveloped particles of 60-80 nm in diameter. Two 1 µg vaccinations with this GETV VLP vaccine, without adjuvant, generated neutralizing antibody responses and protected wild-type C57/BL6 mice against GETV viremia and arthritic disease. The GETV VLP vaccine may find application as a horse and/or pig vaccine in the future.

Trial registration: ClinicalTrials.gov NCT05072080.

Keywords: Baculovirus; Getah virus; Mouse model; Vaccine; Virus-like-particle.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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