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. 2024 Nov;30(11):1004-1006.
doi: 10.1016/j.molmed.2024.07.002. Epub 2024 Jul 14.

Striking senescence with sodium transporter inhibition

Bettina Schock  1 , Steven O'Reilly  2
Affiliations

Striking senescence with sodium transporter inhibition

Bettina Schock et al. Trends Mol Med. 2024 Nov.

Abstract

Senescence is associated with multiple morbidities and therapeutic targeting of these cells is a key aim. In a recent study, Katsuumi et al. found that targeting sodium-glucose co-transporter 2 (SGLT2) promoted immune clearance of senescent cells via programmed cell death-1 ligand (PD-L1) suppression, thus promoting immunosurveillance. This could have profound implications for many age-related diseases, including cancer and frailty.

Keywords: AMPK; age-related diseases; immunosurveillance; senescence; senolysis.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

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