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. 2024 Jul 15;24(1):1877.
doi: 10.1186/s12889-024-19380-2.

Effects of major air pollutants on angina hospitalizations: a correlation study

Anning Zhu  1 , Yongqin Cao  2 , Chunlan Li  3 , Jingze Yu  1 , Miaoxin Liu  1 , Ke Xu  1 , Ye Ruan  4
Affiliations

Effects of major air pollutants on angina hospitalizations: a correlation study

Anning Zhu et al. BMC Public Health. .

Abstract

Background: Angina is a crucial risk signal for cardiovascular disease. However, few studies have evaluated the effects of ambient air pollution exposure on angina.

Objective: We aimed to explore the short-term effects of air pollution on hospitalization for angina and its lag effects.

Methods: We collected data on air pollutant concentrations and angina hospitalizations from 2013 to 2020. Distributed lag nonlinear model (DLNM) was used to evaluate the short-term effects of air pollutants on angina hospitalization under different lag structures. Stratified analysis by sex, age and season was obtained.

Results: A total of 39,110 cases of angina hospitalization were included in the study. The results showed a significant positive correlation between PM2.5, SO2, NO2, and CO and angina hospitalization. Their maximum harmful effects were observed at lag0-7 (RR = 1.042; 95% CI: 1.017, 1.068), lag0-3 (RR = 1.067; 95% CI: 1.005, 1.133), lag0-6 (RR = 1.078; 95% CI: 1.041, 1.117), and lag0-6 (RR = 1.244; 95% CI: 1.109, 1.397), respectively. PM10 did not have an overall risk effect on angina hospitalization, but it did have a risk effect on women and the elderly. O3 was significantly negatively correlated with angina hospitalization, with the most pronounced effect observed at lag0-6 (RR = 0.960; 95% CI: 0.940, 0.982). Stratified analysis results showed that women and the elderly were more susceptible to pollutants, and the adverse effects of pollutants were stronger in the cold season.

Conclusion: Short-term exposure to PM2.5, SO2, NO2, and CO increases the risk of hospitalization for angina.

Keywords: Air pollution; Angina pectoris; Hospitalization; Relative risk.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Time series of angina hospitalizations and pollutant concentrations in Lanzhou, China, 2013–2020
Fig. 2
Fig. 2
Exposure response relationships between six air pollutants and angina hospitalizations
Fig. 3
Fig. 3
Contour plot of relative risk of angina hospitalization with changes in air pollutant concentration and lag days
Fig. 4
Fig. 4
Relative risk (95% CI) of angina hospitalization for each 10 µg/m3 increase in air pollutant concentration (each 1 mg/m3 increase in CO) in single-day lags and cumulative lags
Fig. 5
Fig. 5
Relative risk (95% CI) of angina hospitalization stratified by sex for each 10 µg/m3 increase in air pollutant concentration (each 1 mg/m3 increase in CO) in single-day lags and cumulative lags
Fig. 6
Fig. 6
Relative risk (95% CI) of angina hospitalization stratified by age for each 10 µg/m3 increase in air pollutant concentration (each 1 mg/m3 increase in CO) in single-day lags and cumulative lags
Fig. 7
Fig. 7
Relative risk (95% CI) of angina hospitalization stratified by season for each 10 µg/m3 increase in air pollutant concentration (each 1 mg/m3 increase in CO) in single-day lags and cumulative lags
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References

    1. Crea F, Lanza GA. Angina pectoris and normal coronary arteries: Cardiac syndrome X. Heart. 2004;90(4):457–63. doi: 10.1136/hrt.2003.020594. - DOI - PMC - PubMed
    1. Levy BI, Heusch G, Camici PG. The many faces of myocardial ischaemia and angina. Cardiovasc Res. 2019;115(10):1460–70. doi: 10.1093/cvr/cvz160. - DOI - PubMed
    1. Kloner RA, Chaitman B. Angina and its management. J Cardiovasc Pharmacol Ther. 2017;22(3):199–209. doi: 10.1177/1074248416679733. - DOI - PubMed
    1. Ohman EM. Chronic stable angina. N Engl J Med. 2016;374(12):1167–76. doi: 10.1056/NEJMcp1502240. - DOI - PubMed
    1. Gibbons RJ, Abrams J, Chatterjee K, Daley J, Deedwania PC, Douglas JS, Ferguson TB, Fihn SD, Fraker TD, Gardin JM, et al. ACC/AHA 2002 guideline update for the management of patients with chronic stable angina - summary article - A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the management of patients with chronic stable angina) Circulation. 2003;107(1):149–58. doi: 10.1161/01.CIR.0000047041.66447.29. - DOI - PubMed

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