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Case Reports
. 2024 Oct;71(10):e31194.
doi: 10.1002/pbc.31194. Epub 2024 Jul 14.

Concomitant sickle cell disease and systemic lupus erythematosus: A single-center case series

Ajibike Lapite  1   2 , Luisana M Sánchez  3 , Ana Luiza Altaffer  2   4 , Meredith Rae  2 , Andrea Ann Ramirez  2   4 , Eyal Muscal  2   4 , Cagri Yildirim-Toruner  2   4 , Venée N Tubman  1   2
Affiliations
Case Reports

Concomitant sickle cell disease and systemic lupus erythematosus: A single-center case series

Ajibike Lapite et al. Pediatr Blood Cancer. 2024 Oct.

Abstract

Sickle cell disease (SCD) and systemic lupus erythematosus (SLE) are two uncommon disorders each characterized by multisystemic manifestations. Individuals with SCD exhibit abnormalities in the complement pathway, which may predispose patients to develop autoimmune disorders such as SLE. As many manifestations of SLE mimic those of SCD, diagnosis and therapeutic management of SLE in a patient with known SCD may be delayed. In this study, we describe our institutional experience of diagnosing and managing concomitant SCD and SLE. We offer insights into the complex interplay between these conditions to enhance early recognition and effective management of concurrent SCD and SLE.

Keywords: complement system; sickle cell disease; systemic lupus erythematosus.

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References

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