Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 17:19:100840.
doi: 10.1016/j.onehlt.2024.100840. eCollection 2024 Dec.

Effective intervention of brucellosis prevention in developing countries: A dynamic modelling study

Han Ni  1 , Haoyun Dai  1 , Xuewen Yang  2 , Jin Zhao  2 , Yuxi He  1 , Shanghui Yi  1 , Xiuqin Hong  3 , Wenting Zha  1 , Yuan Lv  1
Affiliations

Effective intervention of brucellosis prevention in developing countries: A dynamic modelling study

Han Ni et al. One Health. .

Abstract

Objective: Brucellosis has a considerable impact on human health and the economy in developing countries. In China, the biggest developing country, brucellosis shifted spread of the epidemic from northern to southern regions. Understanding the transmission characteristic of brucellosis on Hunan province, located in central China, is of great significance for successful control.

Methods: We developed a multi-population and multi-route dynamic model (MPMRDM), which is an animal-human-environment coupled model. The model is an extension of the SEIR model, taking into account direct transmission and indirect transmission. We used the model to explore the spread of brucellosis and evaluate the effectiveness of various intervention strategies.

Results: The animal-to-animal transmission rate was the highest at 5.14 × 10-8, while the environment-to-person transmission rate was the lowest at 9.49 × 10-12. The mean R0 was 1.51. The most effective intervention was taking personal protection, followed by shortening the infection period. Shortening the infection period combined with personal protection is the most effective two-combined intervention strategy. After any comprehensive intervention strategy was implemented, TAR dropped by 90% or more.

Conclusion: The results demonstrate that animal transmission route is essential for controlling human brucellosis. Strengthening personal protection, early detection, and early treatment can effectively control the trend of brucellosis. These results can provide an important reference for optimizing brucellosis intervention plans.

Keywords: Brucellosis; Environment; Intervention; Transmission dynamic model.

PubMed Disclaimer

Conflict of interest statement

On behalf of all authors, the corresponding author states that there are no competing interests to declare.

Figures

Fig. 1
Fig. 1
Flow chart of the model of brucellosis: a. Model 1; b. Model 2.
Fig. 2
Fig. 2
Fitting results of human brucellosis cases of Hunan Province.
Fig. 3
Fig. 3
Effects of separate-intervention strategies. a. shortening the infection period; b. vaccinating susceptible animals; c. environmental disinfection; d. taking personal protection.
Supplementary Fig. S1
Supplementary Fig. S1
Effectiveness of a strategy combining shortening the infection period and vaccinating susceptible animals.
Supplementary Fig. S2
Supplementary Fig. S2
Effectiveness of a strategy combining shortening the infection period and environmental disinfection.
Supplementary Fig. S3
Supplementary Fig. S3
Effectiveness of a strategy combining shortening the infection period and taking personal protection.
Supplementary Fig. S4
Supplementary Fig. S4
Effectiveness of a strategy combining vaccinating susceptible animals with environmental disinfection
Supplementary Fig. S5
Supplementary Fig. S5
Effectiveness of a strategy combining vaccinating susceptible animals with taking personal protection
Supplementary Fig. S6
Supplementary Fig. S6
Effectiveness of a strategy combining environmental disinfection with taking personal protection
Supplementary Fig. S7
Supplementary Fig. S7
Effectiveness of integrated strategies when p = 0.2.
Supplementary Fig. S8
Supplementary Fig. S8
Effectiveness of integrated strategies when p = 0.4.
Supplementary Fig. S9
Supplementary Fig. S9
Effectiveness of integrated strategies when p = 0.6.
Supplementary Fig. S10
Supplementary Fig. S10
Effectiveness of integrated strategies when p = 0.8.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Shakir R. Brucellosis. J. Neurol. Sci. 2021;420 doi: 10.1016/j.jns.2020.117280. - DOI - PubMed
    1. Gheibi A., Khanahmad H., Kashfi K., Sarmadi M., Khorramizadeh M.R. Development of new generation of vaccines for Brucella abortus. Heliyon. 2018;4 doi: 10.1016/j.heliyon.2018.e01079. - DOI - PMC - PubMed
    1. Godfroid J. Brucellosis in wildlife. Rev. Sci. Tech. 2002;21:277. doi: 10.20506/rst.21.2.1333. - DOI - PubMed
    1. Abatih E., Ron L., Speybroeck N., Williams B., Berkvens D. Mathematical analysis of the transmission dynamics of brucellosis among bison. Math. Methods Appl. Sci. 2015;38:3818–3832. doi: 10.1002/mma.3320. - DOI
    1. Pappas G., Papadimitriou P., Akritidis N., Christou L., Tsianos E.V. The new global map of human brucellosis. Lancet Infect. Dis. 2006;6:91–99. doi: 10.1016/S1473-3099(06)70382-6. - DOI - PubMed

LinkOut - more resources