Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Jun 28:12:1424191.
doi: 10.3389/fped.2024.1424191. eCollection 2024.

Case Report: Could topical epidermal growth factor be considered a new therapy for skin injuries in premature infants?

Affiliations
Case Reports

Case Report: Could topical epidermal growth factor be considered a new therapy for skin injuries in premature infants?

F Cossovel et al. Front Pediatr. .

Abstract

In this case report, we present the experience of a premature neonate born at 28 weeks of gestation who, following prolonged respiratory support, developed a pressure injury on the columella despite the implementation of all appropriate preventive techniques. This injury did not improve with standard therapies; therefore, it was necessary to apply a topical galenic therapy containing epidermal growth factor, resulting in complete healing of the lesion.

Keywords: decubit lesion; epithelial growth factor; newborn; preterm; skin injuries.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Lesion on the columella at day 28.
Figure 2
Figure 2
The lesion completely healed after 10 days of topical epidermal growth factor treatment.

References

    1. Imbulana DI, Manley BJ, Dawson JA, Davis PG, Owen LS. Nasal injury in preterm infants receiving non-invasive respiratory support: a systematic review. Arch Dis Child Fetal Neonatal Ed. (2018) 103(1):F29–35. 10.1136/archdischild-2017-313418 - DOI - PubMed
    1. Robertson NJ, McCarthy LS, Hamilton PA, Moss AL. Nasal deformities resulting from flow driver continuous positive airway pressure. Arch Dis Child Fetal Neonatal Ed. (1996) 75(3):F209–12. 10.1136/fn.75.3.F209 - DOI - PMC - PubMed
    1. Fu Y, Li X, Yu Y, Li R, Shi T. Summary of the best evidence for the prevention of nasal injury in preterm infants with nasal noninvasive ventilation. Transl Pediatr. (2024) 13(2):224–35. 10.21037/tp-23-465 - DOI - PMC - PubMed
    1. Fujii K, Sugama J, Okuwa M, Sanada H, Mizokami Y. Incidence and risk factors of pressure ulcers in seven neonatal intensive care units in Japan: a multisite prospective cohort study. Int Wound J. (2010) 7(5):323–8. 10.1111/j.1742-481X.2010.00688.x - DOI - PMC - PubMed
    1. Fischer C, Bertelle V, Hohlfeld J, Forcada-Guex M, Stadelmann-Diaw C, Tolsa JF. Nasal trauma due to continuous positive airway pressure in neonates. Arch Dis Child Fetal Neonatal Ed. (2010) 95(6):F447–51. 10.1136/adc.2009.179416 - DOI - PubMed

Publication types

LinkOut - more resources