Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 28:11:1356839.
doi: 10.3389/fmed.2024.1356839. eCollection 2024.

The anterior scleral thickness in primary open-angle glaucoma with high myopia

Mu Li  1 , Liwen Chen  2 , Zhaoxia Luo  2 , Xiaoqin Yan  2
Affiliations

The anterior scleral thickness in primary open-angle glaucoma with high myopia

Mu Li et al. Front Med (Lausanne). .

Abstract

Purpose: This study aimed to investigate and compare the anterior scleral thickness (AST) among high myopia (HM), primary open-angle glaucoma (POAG), and POAG with HM (HMPOAG) groups.

Methods: Thirty-two HM eyes, 30 POAG eyes, and 31 HMPOAG eyes were included. The Schlemm's canal (SC) area, trabecular meshwork (TM) thickness, scleral spur (SS) length, and AST were measured using swept-source optical coherence tomography. AST was measured at 0 mm (AST0), 1 mm (AST1), 2 mm (AST2), and 3 mm (AST3) from SS.

Results: The HMPOAG group had significantly thinner AST, SS length, and TM thickness than the HM and POAG groups (all p < 0.05). In addition, the SC area of the HMPOAG group was also significantly smaller than that of the HM group (p < 0.001).

Conclusion: The HMPOAG group had the thinnest AST, shortest SS, thinnest TM, and smallest SC. The thinnest AST might contribute to the shortest SS, and further to the thinnest TM and smallest SC in the HMPOAG group. AST might be a novel clinical indicator in the prediction and evaluation of POAG.

Keywords: Schlemm’s canal; anterior scleral thickness; high myopia; primary open-angle glaucoma; trabecular meshwork.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Measurements of anterior scleral thickness (AST0, AST1, AST2, and AST3).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Marcus MW, de Vries MM, Junoy Montolio FG, Jansonius NM. Myopia as a risk factor for open-angle glaucoma: a systematic review and meta-analysis. Ophthalmology. (2011) 118:1989–1994.e2. doi: 10.1016/j.ophtha.2011.03.012, PMID: - DOI - PubMed
    1. Chong RS, Li H, Cheong AJY, Fan Q, Koh V, Raghavan L, et al. . Mendelian randomization implicates bidirectional association between myopia and primary open-Angle Glaucoma or intraocular pressure. Ophthalmology. (2023) 130:394–403. doi: 10.1016/j.ophtha.2022.11.030 - DOI - PubMed
    1. Jonas JB, Wang YX, Dong L, Panda-Jonas S. High myopia and Glaucoma-like optic neuropathy. Asia Pac J Ophthalmol (Phila). (2020) 9:234–8. doi: 10.1097/APO.0000000000000288, PMID: - DOI - PMC - PubMed
    1. Pan CW, Cheung CY, Aung T, Cheung CM, Zheng YF, Wu RY, et al. . Differential associations of myopia with major age-related eye diseases: the Singapore Indian eye study. Ophthalmology. (2013) 120:284–91. doi: 10.1016/j.ophtha.2012.07.065, PMID: - DOI - PubMed
    1. Wong TY, Klein BE, Klein R, Knudtson M, Lee KE. Refractive errors, intraocular pressure, and glaucoma in a white population. Ophthalmology. (2003) 110:211–7. doi: 10.1016/s0161-6420(02)01260-5 - DOI - PubMed

LinkOut - more resources