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. 2024 Jun 24;15(14):4604-4611.
doi: 10.7150/jca.97039. eCollection 2024.

Genetic polymorphism of IL-18 influences susceptibility to lung cancer in population of eastern China

Xu Chen  1 , Yanping Yao  2 , Jianle Lao  3   4 , Hua Li  4 , Hailong Fu  1 , Jun Qiu  1
Affiliations

Genetic polymorphism of IL-18 influences susceptibility to lung cancer in population of eastern China

Xu Chen et al. J Cancer. .

Abstract

The association of Interleukin-18 (IL-18) genetic polymorphism with lung cancer risk has yielded inconsistent findings in previous studies. The current research aims to clarify the relationship of IL-18 gene polymorphism with lung cancer susceptibility through experimental investigation and meta-analysis, providing insights for lung cancer prevention and treatment. We conducted a thorough search of major databases from their inception until March 2024. OR and 95%CI were calculated to know the results of meta-analysis. The IL-18 gene polymorphism was detected using the PCR-RFLP method. Significant associations were detected across all genetic models in allele contrast (A vs. C: Odds Ratio [OR] = 1.29, 95% Confidence Interval [CI] = 1.07-1.55, p = 0.006), homozygote comparison (AA vs. CC: OR = 1.87, 95%CI = 1.34-2.62, p < 0.001), recessive genetic model (AA vs. CT/CC: OR = 1.54, 95%CI = 1.08-2.20, p = 0.018), and dominant genetic model (AA/AC vs. CC: OR = 1.41, 95%CI = 1.12-1.78, p = 0.003). Three genotypes (AA, AC, and CC) were identified for the IL-18 -607 C/A polymorphism, with significant associations noted for the AA genotype and A allele (p = 0.018 and 0.005, respectively). This is the first study which investigates this polymorphism with lung cancer in population of eastern China. The IL-18 -607 C/A polymorphism appears to significantly increase the risk of lung cancer in the population of Eastern China. Further research is imperative to validate these findings.

Keywords: IL-18; gene polymorphism; lung cancer; meta-analysis..

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
PRISMA 2009 Flow Diagram.
Figure 2
Figure 2
Forest plot for the associations between IL-18 gene -607 C/A polymorphism and lung cancer risk through allele contrast (A vs. C). OR, odds ratio; CI, confidence interval.
Figure 3
Figure 3
Forest plot for the associations between IL-18 gene -607 C/A polymorphism and lung cancer risk through homozygote comparison (AA vs. CC). OR, odds ratio; CI, confidence interval.
Figure 4
Figure 4
Forest plot for the associations between IL-18 gene -607 C/A polymorphism and lung cancer risk through recessive genetic model (AA vs. AC/CC). OR, odds ratio; CI, confidence interval.
Figure 5
Figure 5
Forest plot for the associations between IL-18 gene -607 C/A polymorphism and lung cancer risk through dominate genetic model (AA/AC vs. CC). OR, odds ratio; CI, confidence interval.
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