Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 24;15(14):4604-4611.
doi: 10.7150/jca.97039. eCollection 2024.

Genetic polymorphism of IL-18 influences susceptibility to lung cancer in population of eastern China

Xu Chen  1 , Yanping Yao  2 , Jianle Lao  3   4 , Hua Li  4 , Hailong Fu  1 , Jun Qiu  1
Affiliations

Genetic polymorphism of IL-18 influences susceptibility to lung cancer in population of eastern China

Xu Chen et al. J Cancer. .

Abstract

The association of Interleukin-18 (IL-18) genetic polymorphism with lung cancer risk has yielded inconsistent findings in previous studies. The current research aims to clarify the relationship of IL-18 gene polymorphism with lung cancer susceptibility through experimental investigation and meta-analysis, providing insights for lung cancer prevention and treatment. We conducted a thorough search of major databases from their inception until March 2024. OR and 95%CI were calculated to know the results of meta-analysis. The IL-18 gene polymorphism was detected using the PCR-RFLP method. Significant associations were detected across all genetic models in allele contrast (A vs. C: Odds Ratio [OR] = 1.29, 95% Confidence Interval [CI] = 1.07-1.55, p = 0.006), homozygote comparison (AA vs. CC: OR = 1.87, 95%CI = 1.34-2.62, p < 0.001), recessive genetic model (AA vs. CT/CC: OR = 1.54, 95%CI = 1.08-2.20, p = 0.018), and dominant genetic model (AA/AC vs. CC: OR = 1.41, 95%CI = 1.12-1.78, p = 0.003). Three genotypes (AA, AC, and CC) were identified for the IL-18 -607 C/A polymorphism, with significant associations noted for the AA genotype and A allele (p = 0.018 and 0.005, respectively). This is the first study which investigates this polymorphism with lung cancer in population of eastern China. The IL-18 -607 C/A polymorphism appears to significantly increase the risk of lung cancer in the population of Eastern China. Further research is imperative to validate these findings.

Keywords: IL-18; gene polymorphism; lung cancer; meta-analysis..

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
PRISMA 2009 Flow Diagram.
Figure 2
Figure 2
Forest plot for the associations between IL-18 gene -607 C/A polymorphism and lung cancer risk through allele contrast (A vs. C). OR, odds ratio; CI, confidence interval.
Figure 3
Figure 3
Forest plot for the associations between IL-18 gene -607 C/A polymorphism and lung cancer risk through homozygote comparison (AA vs. CC). OR, odds ratio; CI, confidence interval.
Figure 4
Figure 4
Forest plot for the associations between IL-18 gene -607 C/A polymorphism and lung cancer risk through recessive genetic model (AA vs. AC/CC). OR, odds ratio; CI, confidence interval.
Figure 5
Figure 5
Forest plot for the associations between IL-18 gene -607 C/A polymorphism and lung cancer risk through dominate genetic model (AA/AC vs. CC). OR, odds ratio; CI, confidence interval.
See this image and copyright information in PMC

References

    1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A. et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a cancer journal for clinicians. 2021;71:209–49. - PubMed
    1. Malhotra J, Malvezzi M, Negri E, La Vecchia C, Boffetta P. Risk factors for lung cancer worldwide. The European respiratory journal. 2016;48:889–902. - PubMed
    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2018;68:394–424. - PubMed
    1. Tas F, Tilgen Yasasever C, Karabulut S, Tastekin D, Duranyildiz D. Clinical significance of serum interleukin-18 (IL-18) levels in patients with gastric cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2015;70:19–23. - PubMed
    1. Gillies SD, Young D, Lo KM, Roberts S. Biological activity and in vivo clearance of antitumor antibody/cytokine fusion proteins. Bioconjug Chem. 1993;4:230–5. - PubMed

LinkOut - more resources