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. 2024 Apr 21;65(1):56-66.
doi: 10.60787/nmj-v65i1-451. eCollection 2024 Jan-Feb.

Comparative study of the severity of Covid-19 infection between female and male patients

Aboubekr Imzil  1 , Ouassim Mansoury  2   3 , Abdelmajid Oulahbib  1 , Latifa Adarmouch  2   3 , Hind Serhane  1
Affiliations

Comparative study of the severity of Covid-19 infection between female and male patients

Aboubekr Imzil et al. Niger Med J. .

Abstract

Background: Different studies have identified the prognostic factors of COVID-19 infection. These studies have revealed that COVID-19 infection is more severe in males than in females. The aim of our study was to compare the severity of COVID-19 infection between males and females in terms of clinical, biological, radiological, and evolutionary aspects.

Methodology: This is a cross-sectional observational study conducted in patients hospitalized with COVID-19 infection over a 6-month period from 1 August 2021 to 1 February 2022.

Results: The comparison of clinical, biological, radiological, and evolutionary severity factors of covid-19 infection between the two sexes revealed that this infection was more severe in males. Statistically significant differences were noted for the rate of high dimers (p =0.01) and for lung involvement greater than 25% on chest CT (Computed tomography) (p =0.008).

Conclusion: The severity of covid-19 infection in men is due to biological differences between men and women in the renin-angiotensin system, the immune system, genetics, and sex hormones. Further research into the pathophysiological mechanisms behind this finding is needed.

Keywords: Biological Differences.; COVID-19; Gender; Severity.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 2
Figure 2
COVID-19 patients' respiratory rates.
Figure 3:
Figure 3:
Chest CT scan at the time of infection of COVID-19 patients
Figure 4:
Figure 4:
Evolution of COVID-19 patients.
See this image and copyright information in PMC

References

    1. Bradburne AF, Bynoe ML, Tyrrell DA. Effects of a “new” human respiratory virus in volunteers, Br Med J 1967; 3: 767–769. - PMC - PubMed
    1. Gralinski LE, Menachery VD. Return of the coronavirus: 2019-ncov. Viruses 2020; 2(2):135. doi: 10.3390/v12020135. - DOI - PMC - PubMed
    1. Ge HP, Wang XF, Yuan XN, Xiao G, Wang CZ, Deng TC, et al. The epidemiology and clinical information about COVID-19. Eur J Clin Microbiol Infect Dis. 2020;39(6):1011-1019. - PMC - PubMed
    1. Waechter C. Manifestations cliniques et paracliniques de la COVID-19, diagnostic virologique [Clinical and paraclinical features of COVID-19, virological diagnosis]. Npg. 2021. Oct;21(125):297–303.
    1. Zhonghua L, Xing B, Xue ZZ. Epidemiology Working Group for NCIP Epidemic Response, Chinese Center for Disease Control and Prevention The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China Front. Mol. Biosci 2020; 41(2):145–15.

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