Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr 21;65(1):31-39.
doi: 10.60787/nmj-v65i1-449. eCollection 2024 Jan-Feb.

High frequency of co-infection between SARS-CoV-2 and respiratory Adenoviruses in the Pediatric population in Hamadan, Iran

Nazaridoost Ali  1 , Ansari Nastaran  1 , Teimoori Ali  1 , Azizi Jalilian Farid  1   2
Affiliations

High frequency of co-infection between SARS-CoV-2 and respiratory Adenoviruses in the Pediatric population in Hamadan, Iran

Nazaridoost Ali et al. Niger Med J. .

Abstract

Introduction: The presence of other respiratory pathogens in patients with SARS-CoV-2 infection has been described as a striking feature. However, data on adenovirus co-infection rates and clinical impacts in COVID-19 patients is limited. The purpose of this study is to compare the prevalence of respiratory adenoviruses in children under 15 years of age in Positive and Negative SARS-CoV-2 patients.

Methodology: From September 2020 to January 2021, nasopharyngeal swabs were obtained from 280 patients below 15 years old with influenza-like infection symptoms suspected to be COVID-19 and referred to hospitals in Hamadan province. Nucleic acid was extracted using a High Pure Viral Nucleic acid extraction kit for both viral RNA and DNA. Reverse transcription real-time PCR for detecting SARS-CoV-2 and Real-time PCR for Human Adenoviruses were used.

Results: Out of 280 examined samples, 11.7% tested positive for AdV, of which 18 samples originated from the SARS-CoV-2 positive group and 15 samples were from the SARS-CoV-2 negative group. Of 18 co-infected samples, which were categorized in three different ranges of age including, 0-5, 6-10, and 11-15 years old were 11, 4, and 3 patients respectively. Also, 14 patients were hospitalized. Compared with AdV-positive patients, children with Co-infection with SARS CoV-2 had lower levels of white blood cell (WBC) count while erythrocyte sedimentation rate (ESR) and C-reaction protein (CRP) had increased levels.

Conclusion: We report a substantial burden of AdV co-infection in pediatric COVID-19 patients. This study revealed most AdV infections lead to hospitalization and change in paraclinical parameters.

Keywords: Adenoviruses; Co-infection; SARS-CoV-2.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:
Characterization of co-infection cases Figure legend text: Of 18 co-infected samples, which were categorized in three different ranges of age including, 0-5, 6-10, and 11-15 years old were 11, 4, and 3 patients respectively (P=0.66)
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Motta JC, Gómez CC. Adenovirus and novel coronavirus (SARS-Cov2) coinfection: A case report. IDCases. 2020;22:e00936. - PMC - PubMed
    1. Zimmermann P, Curtis N. Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections. Archives of disease in childhood. 2021;106(5):429-39. - PubMed
    1. Ludvigsson JF. A systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta paediatrica. 2020;109(6):1088-95. - PMC - PubMed
    1. Marks KJ, Whitaker M, Anglin O, Milucky J, Patel K, Pham H, et al. Hospitalizations of children and adolescents with laboratory-confirmed COVID-19—COVID-NET, 14 states, July 2021–January 2022. Morbidity and Mortality Weekly Report. 2022;71(7):271. - PMC - PubMed
    1. Vareille M, Kieninger E, Edwards MR, Regamey N. The airway epithelium: soldier in the fight against respiratory viruses. Clinical microbiology reviews. 2011;24(1):210-29. - PMC - PubMed

LinkOut - more resources