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Review
. 2024 Jul 8:17:4405-4417.
doi: 10.2147/JIR.S459185. eCollection 2024.

Lactate and Lactylation in Sepsis: A Comprehensive Review

Sijia Liu #  1   2 , Ting Yang #  1   2 , Qingsong Jiang  1   2 , Liang Zhang  1   2 , Xinhui Shi  1   2 , Xin Liu  3 , Xiaoli Li  1   2
Affiliations
Review

Lactate and Lactylation in Sepsis: A Comprehensive Review

Sijia Liu et al. J Inflamm Res. .

Abstract

Sepsis is a disorder of the immune response to infection or infectious factors with high morbidity and mortality in clinical settings. The lactylation of lysine residues, fueled by lactate, plays a pivotal role in its pathophysiology. In conducting a literature review on sepsis-related research, we employed a systematic approach to ensure comprehensiveness and accuracy. Initially, we conducted an extensive literature search through the PubMed database, utilizing a range of keywords including "sepsis", "lactate", "lactylation", and "epigenetic modification". The aim was to capture the most recent research related to the pathophysiological mechanisms of sepsis, metabolic disorders, and the role of lactylation. The results of the literature review revealed a close link between sepsis and metabolic dysfunction, particularly the pivotal role of lactylation in regulating immune responses and inflammatory processes. Lactate, not only an energy metabolic byproduct produced during glycolysis, affects the activity of various proteins, including those involved in immune regulation and cell signaling, through lactylation. In the context of sepsis, changes in the levels of lactylation may be closely associated with the severity and prognosis of the disease. In summary, lactylation, as an emerging type of epigenetic modification, provides a new perspective for the diagnosis and treatment of sepsis. Future research needs to further elucidate the exact mechanisms of lactylation in sepsis and explore its potential as a therapeutic target.

Keywords: epigenetic modification; lactate; lactylation; sepsis.

Plain language summary

The annual incidence and mortality rates associated with sepsis are on the rise, and to date, no medications or therapies have been proven effective in clinical practice. Glycolysis plays a pivotal role in regulating lactylation, a process derived from lactate generated by cellular glucose metabolism. In the context of sepsis, elevated lactate levels are indicative of a poor prognosis. It is imperative to delve into the mechanisms underlying lactylation alterations during sepsis to enhance our comprehension of its complex pathophysiology and to pinpoint innovative therapeutic targets for the condition.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

None
Graphical abstract
Figure 1
Figure 1
The role of lactylation in sepsis. Lactate shuttles through organs, cells, and cells through monocarboxylate transporter and G protein-coupled receptor 81. Under the conditions of aerobic or anoxic and bacterial stimulation, the lactate produced by glycolysis catalyzes the production of lactyl-CoA, and the lactate is transferred to histone through a writer or an eraser and participates in the lactylation of lysine residues. PI3K-regulated B-cell adapter regulates FOXO1 and GSK3β. Reducing histone lactylation affects the expression of damage repair genes, and affects the transformation of inflammatory macrophages to repair macrophages. Lactylation of histone H3K18 promotes the expression of damage repair gene Arg1 and polarization to M2-type macrophages.
See this image and copyright information in PMC

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